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Tryptophan Metabolism and Its Relationship with Depression and Cognitive Impairment Among HIV-infected Individuals

OBJECTIVE: Cognitive impairment (CI) and major depressive disorder (MDD) remain prevalent in treated HIV-1 disease; however, the pathogenesis remains elusive. A possible contributing mechanism is immune-mediated degradation of tryptophan (TRP) via the kynurenine (KYN) pathway, resulting in decreased...

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Detalles Bibliográficos
Autores principales:	Keegan, Michael R., Chittiprol, Seetharamaiah, Letendre, Scott L., Winston, Alan, Fuchs, Dietmar, Boasso, Adriano, Iudicello, Jennifer, Ellis, Ronald J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Libertas Academica 2016
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083113/ https://www.ncbi.nlm.nih.gov/pubmed/27812290 http://dx.doi.org/10.4137/IJTR.S36464

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