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Is intraoperative frozen section analysis of the proximal bile ducts in hilar cholangiocarcinoma of limited value?

Mantel et al. showed that the use of intraoperative frozen section analysis of the proximal bile ducts has a limited contribution in obtaining secondary R0 resections and final resection status had no impact on recurrence rate in hilar cholangiocarcinoma. However, the accuracy, sensitivity, and spec...

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Detalles Bibliográficos
Autores principales: Ma, Wen‐Jie, Shrestha, Anuj, Li, Fu‐Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083738/
https://www.ncbi.nlm.nih.gov/pubmed/27686472
http://dx.doi.org/10.1002/cam4.920
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author Ma, Wen‐Jie
Shrestha, Anuj
Li, Fu‐Yu
author_facet Ma, Wen‐Jie
Shrestha, Anuj
Li, Fu‐Yu
author_sort Ma, Wen‐Jie
collection PubMed
description Mantel et al. showed that the use of intraoperative frozen section analysis of the proximal bile ducts has a limited contribution in obtaining secondary R0 resections and final resection status had no impact on recurrence rate in hilar cholangiocarcinoma. However, the accuracy, sensitivity, and specificity of intraoperative frozen section analysis were determined by the specific pathologic features of the tumor and the different experienced pathologists in different pathology laboratories. It has been demonstrated that tumor‐free resection margin (R0) is the most prognostic factor for survival, as well as the only factor that can be modified by the surgeons. Ribero et al. reported an improvement in prognosis was found in the secondary R0 group. As the conclusion given by Mantel et al. and Shingu et al., which is contrary to Ribero et al. Before the real role of intraoperative frozen section in the analysis of the margin of proximal bile ducts in treating hilar cholangiocarcinoma is concluded, further studies are still needed.
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spelling pubmed-50837382016-10-31 Is intraoperative frozen section analysis of the proximal bile ducts in hilar cholangiocarcinoma of limited value? Ma, Wen‐Jie Shrestha, Anuj Li, Fu‐Yu Cancer Med Clinical Cancer Research Mantel et al. showed that the use of intraoperative frozen section analysis of the proximal bile ducts has a limited contribution in obtaining secondary R0 resections and final resection status had no impact on recurrence rate in hilar cholangiocarcinoma. However, the accuracy, sensitivity, and specificity of intraoperative frozen section analysis were determined by the specific pathologic features of the tumor and the different experienced pathologists in different pathology laboratories. It has been demonstrated that tumor‐free resection margin (R0) is the most prognostic factor for survival, as well as the only factor that can be modified by the surgeons. Ribero et al. reported an improvement in prognosis was found in the secondary R0 group. As the conclusion given by Mantel et al. and Shingu et al., which is contrary to Ribero et al. Before the real role of intraoperative frozen section in the analysis of the margin of proximal bile ducts in treating hilar cholangiocarcinoma is concluded, further studies are still needed. John Wiley and Sons Inc. 2016-09-29 /pmc/articles/PMC5083738/ /pubmed/27686472 http://dx.doi.org/10.1002/cam4.920 Text en © 2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Cancer Research
Ma, Wen‐Jie
Shrestha, Anuj
Li, Fu‐Yu
Is intraoperative frozen section analysis of the proximal bile ducts in hilar cholangiocarcinoma of limited value?
title Is intraoperative frozen section analysis of the proximal bile ducts in hilar cholangiocarcinoma of limited value?
title_full Is intraoperative frozen section analysis of the proximal bile ducts in hilar cholangiocarcinoma of limited value?
title_fullStr Is intraoperative frozen section analysis of the proximal bile ducts in hilar cholangiocarcinoma of limited value?
title_full_unstemmed Is intraoperative frozen section analysis of the proximal bile ducts in hilar cholangiocarcinoma of limited value?
title_short Is intraoperative frozen section analysis of the proximal bile ducts in hilar cholangiocarcinoma of limited value?
title_sort is intraoperative frozen section analysis of the proximal bile ducts in hilar cholangiocarcinoma of limited value?
topic Clinical Cancer Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083738/
https://www.ncbi.nlm.nih.gov/pubmed/27686472
http://dx.doi.org/10.1002/cam4.920
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