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Correlates of disease-specific knowledge among patients with chronic hepatitis B or hepatitis C infection in India

BACKGROUND: Patient knowledge about chronic diseases increases health-promoting behaviors and improves clinical outcomes. We assessed this association for patients with chronic viral hepatitis. METHODS: Untreated patients chronically infected with HBV (n = 500) or HCV (n = 500) were enrolled at 19 c...

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Autores principales: Tamayo, Aracely, Shah, Samir R., Bhatia, Shobna, Chowdhury, Abhijit, Rao, Padaki N., Dinh, Phillip, Knox, Steven J., Gaggar, Anuj, Subramanian, G. Mani, Mohan, Viswanathan G., Sood, Ajit, Mehta, Rajiv, Sarin, Shiv K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer India 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083769/
https://www.ncbi.nlm.nih.gov/pubmed/27146692
http://dx.doi.org/10.1007/s12072-016-9728-3
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author Tamayo, Aracely
Shah, Samir R.
Bhatia, Shobna
Chowdhury, Abhijit
Rao, Padaki N.
Dinh, Phillip
Knox, Steven J.
Gaggar, Anuj
Subramanian, G. Mani
Mohan, Viswanathan G.
Sood, Ajit
Mehta, Rajiv
Sarin, Shiv K.
author_facet Tamayo, Aracely
Shah, Samir R.
Bhatia, Shobna
Chowdhury, Abhijit
Rao, Padaki N.
Dinh, Phillip
Knox, Steven J.
Gaggar, Anuj
Subramanian, G. Mani
Mohan, Viswanathan G.
Sood, Ajit
Mehta, Rajiv
Sarin, Shiv K.
author_sort Tamayo, Aracely
collection PubMed
description BACKGROUND: Patient knowledge about chronic diseases increases health-promoting behaviors and improves clinical outcomes. We assessed this association for patients with chronic viral hepatitis. METHODS: Untreated patients chronically infected with HBV (n = 500) or HCV (n = 500) were enrolled at 19 centers across India. A survey, adapted from the US CDC National Health and Nutrition Examination Survey (NHANES) questionnaire, was administered at a single visit to assess HBV/HCV knowledge, community disease awareness, treatment quality, and healthcare barriers. We developed the India Hepatitis Knowledge Index (IHKI), where a higher IHKI score (range 0–10) indicates increased hepatitis knowledge. Multivariate regression models evaluated demographic and disease factors. RESULTS: The overall mean IHKI score was 5.6 out of 10, with higher scores among patients with HBV (5.9) than HCV (5.3); p < 0.001. In HBV patients lower IHKI was associated with shorter disease duration, government clinic attendance (p < 0.0001), fewer personal experiences with HBV (p < 0.0001), and residing in northern India. Among HCV patients, lower IHKI was associated with shorter disease duration, community (p < 0.0001) and government clinic attendance (p < 0.0001), and fewer personal experiences with HCV (p < 0.0001). Among HBV patients, IHKI was independently associated with disease severity as assessed by MELD score, albumin, and APRI. This association was strongest for HBV patients with elevated ALT and HBV DNA >2000 IU/ml. Among HCV patients, IHKI results had no significant associations with disease severity. CONCLUSIONS: The association of IHKI with disease underscores the need to understand connections between hepatitis knowledge and progression and may guide efforts to address patient education and awareness of chronic viral hepatitis in India. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s12072-016-9728-3) contains supplementary material, which is available to authorized users.
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spelling pubmed-50837692016-11-14 Correlates of disease-specific knowledge among patients with chronic hepatitis B or hepatitis C infection in India Tamayo, Aracely Shah, Samir R. Bhatia, Shobna Chowdhury, Abhijit Rao, Padaki N. Dinh, Phillip Knox, Steven J. Gaggar, Anuj Subramanian, G. Mani Mohan, Viswanathan G. Sood, Ajit Mehta, Rajiv Sarin, Shiv K. Hepatol Int Original Article BACKGROUND: Patient knowledge about chronic diseases increases health-promoting behaviors and improves clinical outcomes. We assessed this association for patients with chronic viral hepatitis. METHODS: Untreated patients chronically infected with HBV (n = 500) or HCV (n = 500) were enrolled at 19 centers across India. A survey, adapted from the US CDC National Health and Nutrition Examination Survey (NHANES) questionnaire, was administered at a single visit to assess HBV/HCV knowledge, community disease awareness, treatment quality, and healthcare barriers. We developed the India Hepatitis Knowledge Index (IHKI), where a higher IHKI score (range 0–10) indicates increased hepatitis knowledge. Multivariate regression models evaluated demographic and disease factors. RESULTS: The overall mean IHKI score was 5.6 out of 10, with higher scores among patients with HBV (5.9) than HCV (5.3); p < 0.001. In HBV patients lower IHKI was associated with shorter disease duration, government clinic attendance (p < 0.0001), fewer personal experiences with HBV (p < 0.0001), and residing in northern India. Among HCV patients, lower IHKI was associated with shorter disease duration, community (p < 0.0001) and government clinic attendance (p < 0.0001), and fewer personal experiences with HCV (p < 0.0001). Among HBV patients, IHKI was independently associated with disease severity as assessed by MELD score, albumin, and APRI. This association was strongest for HBV patients with elevated ALT and HBV DNA >2000 IU/ml. Among HCV patients, IHKI results had no significant associations with disease severity. CONCLUSIONS: The association of IHKI with disease underscores the need to understand connections between hepatitis knowledge and progression and may guide efforts to address patient education and awareness of chronic viral hepatitis in India. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s12072-016-9728-3) contains supplementary material, which is available to authorized users. Springer India 2016-05-04 /pmc/articles/PMC5083769/ /pubmed/27146692 http://dx.doi.org/10.1007/s12072-016-9728-3 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Tamayo, Aracely
Shah, Samir R.
Bhatia, Shobna
Chowdhury, Abhijit
Rao, Padaki N.
Dinh, Phillip
Knox, Steven J.
Gaggar, Anuj
Subramanian, G. Mani
Mohan, Viswanathan G.
Sood, Ajit
Mehta, Rajiv
Sarin, Shiv K.
Correlates of disease-specific knowledge among patients with chronic hepatitis B or hepatitis C infection in India
title Correlates of disease-specific knowledge among patients with chronic hepatitis B or hepatitis C infection in India
title_full Correlates of disease-specific knowledge among patients with chronic hepatitis B or hepatitis C infection in India
title_fullStr Correlates of disease-specific knowledge among patients with chronic hepatitis B or hepatitis C infection in India
title_full_unstemmed Correlates of disease-specific knowledge among patients with chronic hepatitis B or hepatitis C infection in India
title_short Correlates of disease-specific knowledge among patients with chronic hepatitis B or hepatitis C infection in India
title_sort correlates of disease-specific knowledge among patients with chronic hepatitis b or hepatitis c infection in india
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083769/
https://www.ncbi.nlm.nih.gov/pubmed/27146692
http://dx.doi.org/10.1007/s12072-016-9728-3
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