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Effects of Aspirin on Endothelial Function and Hypertension

PURPOSE OF REVIEW: Endothelial dysfunction is intimately related to the development of various cardiovascular diseases, including hypertension, and is often used as a target for pharmacological treatment. The scope of this review is to assess effects of aspirin on endothelial function and their clin...

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Autores principales: Dzeshka, Mikhail S., Shantsila, Alena, Lip, Gregory Y. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083775/
https://www.ncbi.nlm.nih.gov/pubmed/27787837
http://dx.doi.org/10.1007/s11906-016-0688-8
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author Dzeshka, Mikhail S.
Shantsila, Alena
Lip, Gregory Y. H.
author_facet Dzeshka, Mikhail S.
Shantsila, Alena
Lip, Gregory Y. H.
author_sort Dzeshka, Mikhail S.
collection PubMed
description PURPOSE OF REVIEW: Endothelial dysfunction is intimately related to the development of various cardiovascular diseases, including hypertension, and is often used as a target for pharmacological treatment. The scope of this review is to assess effects of aspirin on endothelial function and their clinical implication in arterial hypertension. RECENT FINDINGS: Emerging data indicate the role of platelets in the development of vascular inflammation due to the release of proinflammatory mediators, for example, triggered largely by thromboxane. Vascular inflammation further promotes oxidative stress, diminished synthesis of vasodilators, proaggregatory and procoagulant state. These changes translate into vasoconstriction, impaired circulation and thrombotic complications. Aspirin inhibits thromboxane synthesis, abolishes platelets activation and acetylates enzymes switching them to the synthesis of anti-inflammatory substances. SUMMARY: Aspirin pleiotropic effects have not been fully elucidated yet. In secondary prevention studies, the decrease in cardiovascular events with aspirin outweighs bleeding risks, but this is not the case in primary prevention settings. Ongoing trials will provide more evidence on whether to expand the use of aspirin or stay within current recommendations.
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spelling pubmed-50837752016-11-14 Effects of Aspirin on Endothelial Function and Hypertension Dzeshka, Mikhail S. Shantsila, Alena Lip, Gregory Y. H. Curr Hypertens Rep Antihypertensive Agents: Mechanisms of Drug Action (ME Ernst, Section Editor) PURPOSE OF REVIEW: Endothelial dysfunction is intimately related to the development of various cardiovascular diseases, including hypertension, and is often used as a target for pharmacological treatment. The scope of this review is to assess effects of aspirin on endothelial function and their clinical implication in arterial hypertension. RECENT FINDINGS: Emerging data indicate the role of platelets in the development of vascular inflammation due to the release of proinflammatory mediators, for example, triggered largely by thromboxane. Vascular inflammation further promotes oxidative stress, diminished synthesis of vasodilators, proaggregatory and procoagulant state. These changes translate into vasoconstriction, impaired circulation and thrombotic complications. Aspirin inhibits thromboxane synthesis, abolishes platelets activation and acetylates enzymes switching them to the synthesis of anti-inflammatory substances. SUMMARY: Aspirin pleiotropic effects have not been fully elucidated yet. In secondary prevention studies, the decrease in cardiovascular events with aspirin outweighs bleeding risks, but this is not the case in primary prevention settings. Ongoing trials will provide more evidence on whether to expand the use of aspirin or stay within current recommendations. Springer US 2016-10-27 2016 /pmc/articles/PMC5083775/ /pubmed/27787837 http://dx.doi.org/10.1007/s11906-016-0688-8 Text en © The Author(s) 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Antihypertensive Agents: Mechanisms of Drug Action (ME Ernst, Section Editor)
Dzeshka, Mikhail S.
Shantsila, Alena
Lip, Gregory Y. H.
Effects of Aspirin on Endothelial Function and Hypertension
title Effects of Aspirin on Endothelial Function and Hypertension
title_full Effects of Aspirin on Endothelial Function and Hypertension
title_fullStr Effects of Aspirin on Endothelial Function and Hypertension
title_full_unstemmed Effects of Aspirin on Endothelial Function and Hypertension
title_short Effects of Aspirin on Endothelial Function and Hypertension
title_sort effects of aspirin on endothelial function and hypertension
topic Antihypertensive Agents: Mechanisms of Drug Action (ME Ernst, Section Editor)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083775/
https://www.ncbi.nlm.nih.gov/pubmed/27787837
http://dx.doi.org/10.1007/s11906-016-0688-8
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