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In search of novel ligands using a structure-based approach: a case study on the adenosine A(2A) receptor
In this work, we present a case study to explore the challenges associated with finding novel molecules for a receptor that has been studied in depth and has a wealth of chemical information available. Specifically, we apply a previously described protocol that incorporates explicit water molecules...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083784/ https://www.ncbi.nlm.nih.gov/pubmed/27629350 http://dx.doi.org/10.1007/s10822-016-9963-7 |