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Fibrosis in nonalcoholic fatty liver disease: Noninvasive assessment using computed tomography volumetry

AIM: To evaluate the diagnostic performance of computed tomography (CT) volumetry for discriminating the fibrosis stage in patients with nonalcoholic fatty liver disease (NAFLD). METHODS: A total of 38 NAFLD patients were enrolled. On the basis of CT imaging, the volumes of total, left lateral segme...

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Autores principales: Fujita, Nobuhiro, Nishie, Akihiro, Asayama, Yoshiki, Ishigami, Kousei, Ushijima, Yasuhiro, Takayama, Yukihisa, Okamoto, Daisuke, Shirabe, Ken, Yoshizumi, Tomoharu, Kotoh, Kazuhiro, Furusyo, Norihiro, Hida, Tomoyuki, Oda, Yoshinao, Fujioka, Taisuke, Honda, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083800/
https://www.ncbi.nlm.nih.gov/pubmed/27833386
http://dx.doi.org/10.3748/wjg.v22.i40.8949
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author Fujita, Nobuhiro
Nishie, Akihiro
Asayama, Yoshiki
Ishigami, Kousei
Ushijima, Yasuhiro
Takayama, Yukihisa
Okamoto, Daisuke
Shirabe, Ken
Yoshizumi, Tomoharu
Kotoh, Kazuhiro
Furusyo, Norihiro
Hida, Tomoyuki
Oda, Yoshinao
Fujioka, Taisuke
Honda, Hiroshi
author_facet Fujita, Nobuhiro
Nishie, Akihiro
Asayama, Yoshiki
Ishigami, Kousei
Ushijima, Yasuhiro
Takayama, Yukihisa
Okamoto, Daisuke
Shirabe, Ken
Yoshizumi, Tomoharu
Kotoh, Kazuhiro
Furusyo, Norihiro
Hida, Tomoyuki
Oda, Yoshinao
Fujioka, Taisuke
Honda, Hiroshi
author_sort Fujita, Nobuhiro
collection PubMed
description AIM: To evaluate the diagnostic performance of computed tomography (CT) volumetry for discriminating the fibrosis stage in patients with nonalcoholic fatty liver disease (NAFLD). METHODS: A total of 38 NAFLD patients were enrolled. On the basis of CT imaging, the volumes of total, left lateral segment (LLS), left medial segment, caudate lobe, and right lobe (RL) of the liver were calculated with a dedicated liver application. The relationship between the volume percentage of each area and fibrosis stage was analyzed using Spearman’s rank correlation coefficient. A receiver operating characteristic (ROC) curve analysis was performed to determine the accuracy of CT volumetry for discriminating fibrosis stage. RESULTS: The volume percentages of the caudate lobe and the LLS significantly increased with the fibrosis stage (r = 0.815, P < 0.001; and r = 0.465, P = 0.003, respectively). Contrarily, the volume percentage of the RL significantly decreased with fibrosis stage (r = -0.563, P < 0.001). The volume percentage of the caudate lobe had the best diagnostic accuracy for staging fibrosis, and the area under the ROC curve values for discriminating fibrosis stage were as follows: ≥ F1, 0.896; ≥ F2, 0.929; ≥ F3, 0.955; and ≥ F4, 0.923. The best cut-off for advanced fibrosis (F3-F4) was 4.789%, 85.7% sensitivity and 94.1% specificity. CONCLUSION: The volume percentage of the caudate lobe calculated by CT volumetry is a useful diagnostic parameter for staging fibrosis in NAFLD patients.
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spelling pubmed-50838002016-11-10 Fibrosis in nonalcoholic fatty liver disease: Noninvasive assessment using computed tomography volumetry Fujita, Nobuhiro Nishie, Akihiro Asayama, Yoshiki Ishigami, Kousei Ushijima, Yasuhiro Takayama, Yukihisa Okamoto, Daisuke Shirabe, Ken Yoshizumi, Tomoharu Kotoh, Kazuhiro Furusyo, Norihiro Hida, Tomoyuki Oda, Yoshinao Fujioka, Taisuke Honda, Hiroshi World J Gastroenterol Retrospective Study AIM: To evaluate the diagnostic performance of computed tomography (CT) volumetry for discriminating the fibrosis stage in patients with nonalcoholic fatty liver disease (NAFLD). METHODS: A total of 38 NAFLD patients were enrolled. On the basis of CT imaging, the volumes of total, left lateral segment (LLS), left medial segment, caudate lobe, and right lobe (RL) of the liver were calculated with a dedicated liver application. The relationship between the volume percentage of each area and fibrosis stage was analyzed using Spearman’s rank correlation coefficient. A receiver operating characteristic (ROC) curve analysis was performed to determine the accuracy of CT volumetry for discriminating fibrosis stage. RESULTS: The volume percentages of the caudate lobe and the LLS significantly increased with the fibrosis stage (r = 0.815, P < 0.001; and r = 0.465, P = 0.003, respectively). Contrarily, the volume percentage of the RL significantly decreased with fibrosis stage (r = -0.563, P < 0.001). The volume percentage of the caudate lobe had the best diagnostic accuracy for staging fibrosis, and the area under the ROC curve values for discriminating fibrosis stage were as follows: ≥ F1, 0.896; ≥ F2, 0.929; ≥ F3, 0.955; and ≥ F4, 0.923. The best cut-off for advanced fibrosis (F3-F4) was 4.789%, 85.7% sensitivity and 94.1% specificity. CONCLUSION: The volume percentage of the caudate lobe calculated by CT volumetry is a useful diagnostic parameter for staging fibrosis in NAFLD patients. Baishideng Publishing Group Inc 2016-10-28 2016-10-28 /pmc/articles/PMC5083800/ /pubmed/27833386 http://dx.doi.org/10.3748/wjg.v22.i40.8949 Text en ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Retrospective Study
Fujita, Nobuhiro
Nishie, Akihiro
Asayama, Yoshiki
Ishigami, Kousei
Ushijima, Yasuhiro
Takayama, Yukihisa
Okamoto, Daisuke
Shirabe, Ken
Yoshizumi, Tomoharu
Kotoh, Kazuhiro
Furusyo, Norihiro
Hida, Tomoyuki
Oda, Yoshinao
Fujioka, Taisuke
Honda, Hiroshi
Fibrosis in nonalcoholic fatty liver disease: Noninvasive assessment using computed tomography volumetry
title Fibrosis in nonalcoholic fatty liver disease: Noninvasive assessment using computed tomography volumetry
title_full Fibrosis in nonalcoholic fatty liver disease: Noninvasive assessment using computed tomography volumetry
title_fullStr Fibrosis in nonalcoholic fatty liver disease: Noninvasive assessment using computed tomography volumetry
title_full_unstemmed Fibrosis in nonalcoholic fatty liver disease: Noninvasive assessment using computed tomography volumetry
title_short Fibrosis in nonalcoholic fatty liver disease: Noninvasive assessment using computed tomography volumetry
title_sort fibrosis in nonalcoholic fatty liver disease: noninvasive assessment using computed tomography volumetry
topic Retrospective Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083800/
https://www.ncbi.nlm.nih.gov/pubmed/27833386
http://dx.doi.org/10.3748/wjg.v22.i40.8949
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