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Fibrosis in nonalcoholic fatty liver disease: Noninvasive assessment using computed tomography volumetry
AIM: To evaluate the diagnostic performance of computed tomography (CT) volumetry for discriminating the fibrosis stage in patients with nonalcoholic fatty liver disease (NAFLD). METHODS: A total of 38 NAFLD patients were enrolled. On the basis of CT imaging, the volumes of total, left lateral segme...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083800/ https://www.ncbi.nlm.nih.gov/pubmed/27833386 http://dx.doi.org/10.3748/wjg.v22.i40.8949 |
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author | Fujita, Nobuhiro Nishie, Akihiro Asayama, Yoshiki Ishigami, Kousei Ushijima, Yasuhiro Takayama, Yukihisa Okamoto, Daisuke Shirabe, Ken Yoshizumi, Tomoharu Kotoh, Kazuhiro Furusyo, Norihiro Hida, Tomoyuki Oda, Yoshinao Fujioka, Taisuke Honda, Hiroshi |
author_facet | Fujita, Nobuhiro Nishie, Akihiro Asayama, Yoshiki Ishigami, Kousei Ushijima, Yasuhiro Takayama, Yukihisa Okamoto, Daisuke Shirabe, Ken Yoshizumi, Tomoharu Kotoh, Kazuhiro Furusyo, Norihiro Hida, Tomoyuki Oda, Yoshinao Fujioka, Taisuke Honda, Hiroshi |
author_sort | Fujita, Nobuhiro |
collection | PubMed |
description | AIM: To evaluate the diagnostic performance of computed tomography (CT) volumetry for discriminating the fibrosis stage in patients with nonalcoholic fatty liver disease (NAFLD). METHODS: A total of 38 NAFLD patients were enrolled. On the basis of CT imaging, the volumes of total, left lateral segment (LLS), left medial segment, caudate lobe, and right lobe (RL) of the liver were calculated with a dedicated liver application. The relationship between the volume percentage of each area and fibrosis stage was analyzed using Spearman’s rank correlation coefficient. A receiver operating characteristic (ROC) curve analysis was performed to determine the accuracy of CT volumetry for discriminating fibrosis stage. RESULTS: The volume percentages of the caudate lobe and the LLS significantly increased with the fibrosis stage (r = 0.815, P < 0.001; and r = 0.465, P = 0.003, respectively). Contrarily, the volume percentage of the RL significantly decreased with fibrosis stage (r = -0.563, P < 0.001). The volume percentage of the caudate lobe had the best diagnostic accuracy for staging fibrosis, and the area under the ROC curve values for discriminating fibrosis stage were as follows: ≥ F1, 0.896; ≥ F2, 0.929; ≥ F3, 0.955; and ≥ F4, 0.923. The best cut-off for advanced fibrosis (F3-F4) was 4.789%, 85.7% sensitivity and 94.1% specificity. CONCLUSION: The volume percentage of the caudate lobe calculated by CT volumetry is a useful diagnostic parameter for staging fibrosis in NAFLD patients. |
format | Online Article Text |
id | pubmed-5083800 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-50838002016-11-10 Fibrosis in nonalcoholic fatty liver disease: Noninvasive assessment using computed tomography volumetry Fujita, Nobuhiro Nishie, Akihiro Asayama, Yoshiki Ishigami, Kousei Ushijima, Yasuhiro Takayama, Yukihisa Okamoto, Daisuke Shirabe, Ken Yoshizumi, Tomoharu Kotoh, Kazuhiro Furusyo, Norihiro Hida, Tomoyuki Oda, Yoshinao Fujioka, Taisuke Honda, Hiroshi World J Gastroenterol Retrospective Study AIM: To evaluate the diagnostic performance of computed tomography (CT) volumetry for discriminating the fibrosis stage in patients with nonalcoholic fatty liver disease (NAFLD). METHODS: A total of 38 NAFLD patients were enrolled. On the basis of CT imaging, the volumes of total, left lateral segment (LLS), left medial segment, caudate lobe, and right lobe (RL) of the liver were calculated with a dedicated liver application. The relationship between the volume percentage of each area and fibrosis stage was analyzed using Spearman’s rank correlation coefficient. A receiver operating characteristic (ROC) curve analysis was performed to determine the accuracy of CT volumetry for discriminating fibrosis stage. RESULTS: The volume percentages of the caudate lobe and the LLS significantly increased with the fibrosis stage (r = 0.815, P < 0.001; and r = 0.465, P = 0.003, respectively). Contrarily, the volume percentage of the RL significantly decreased with fibrosis stage (r = -0.563, P < 0.001). The volume percentage of the caudate lobe had the best diagnostic accuracy for staging fibrosis, and the area under the ROC curve values for discriminating fibrosis stage were as follows: ≥ F1, 0.896; ≥ F2, 0.929; ≥ F3, 0.955; and ≥ F4, 0.923. The best cut-off for advanced fibrosis (F3-F4) was 4.789%, 85.7% sensitivity and 94.1% specificity. CONCLUSION: The volume percentage of the caudate lobe calculated by CT volumetry is a useful diagnostic parameter for staging fibrosis in NAFLD patients. Baishideng Publishing Group Inc 2016-10-28 2016-10-28 /pmc/articles/PMC5083800/ /pubmed/27833386 http://dx.doi.org/10.3748/wjg.v22.i40.8949 Text en ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Retrospective Study Fujita, Nobuhiro Nishie, Akihiro Asayama, Yoshiki Ishigami, Kousei Ushijima, Yasuhiro Takayama, Yukihisa Okamoto, Daisuke Shirabe, Ken Yoshizumi, Tomoharu Kotoh, Kazuhiro Furusyo, Norihiro Hida, Tomoyuki Oda, Yoshinao Fujioka, Taisuke Honda, Hiroshi Fibrosis in nonalcoholic fatty liver disease: Noninvasive assessment using computed tomography volumetry |
title | Fibrosis in nonalcoholic fatty liver disease: Noninvasive assessment using computed tomography volumetry |
title_full | Fibrosis in nonalcoholic fatty liver disease: Noninvasive assessment using computed tomography volumetry |
title_fullStr | Fibrosis in nonalcoholic fatty liver disease: Noninvasive assessment using computed tomography volumetry |
title_full_unstemmed | Fibrosis in nonalcoholic fatty liver disease: Noninvasive assessment using computed tomography volumetry |
title_short | Fibrosis in nonalcoholic fatty liver disease: Noninvasive assessment using computed tomography volumetry |
title_sort | fibrosis in nonalcoholic fatty liver disease: noninvasive assessment using computed tomography volumetry |
topic | Retrospective Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083800/ https://www.ncbi.nlm.nih.gov/pubmed/27833386 http://dx.doi.org/10.3748/wjg.v22.i40.8949 |
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