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Oropharyngeal acid reflux and motility abnormalities of the proximal esophagus

AIM: To investigate the relationship between pathological oropharyngeal (OP) acid exposure and esophageal motility in patients with extra-esophageal syndromes. METHODS: In this prospective study we enrolled consecutive outpatients with extra-esophageal symptoms suspected to be related to gastroesoph...

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Autores principales: Passaretti, Sandro, Mazzoleni, Giorgia, Vailati, Cristian, Testoni, Pier Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083804/
https://www.ncbi.nlm.nih.gov/pubmed/27833390
http://dx.doi.org/10.3748/wjg.v22.i40.8991
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author Passaretti, Sandro
Mazzoleni, Giorgia
Vailati, Cristian
Testoni, Pier Alberto
author_facet Passaretti, Sandro
Mazzoleni, Giorgia
Vailati, Cristian
Testoni, Pier Alberto
author_sort Passaretti, Sandro
collection PubMed
description AIM: To investigate the relationship between pathological oropharyngeal (OP) acid exposure and esophageal motility in patients with extra-esophageal syndromes. METHODS: In this prospective study we enrolled consecutive outpatients with extra-esophageal symptoms suspected to be related to gastroesophageal reflux disease (GERD). We enrolled only patients with a reflux symptom index (RSI) score-higher than 13 and with previous lung, allergy and ear, nose and throat evaluations excluding other specific diagnoses. All patients underwent 24-h OP pH-metry with the Dx probe and esophageal high-resolution manometry (HRM). Patients were divided into two groups on the basis of a normal or pathological pH-metric finding (Ryan Score) and all manometric characteristics of the two groups were compared. RESULTS: We examined 135 patients with chronic extra-esophageal syndromes. Fifty-one were considered eligible for the study. Of these, 42 decided to participate in the protocol. Patients were divided into two groups on the basis of normal or pathological OP acid exposure. All the HRM parameters were compared for the two groups. Significant differences were found in the median upper esophageal sphincter resting pressure (median 71 mmHg vs 126 mmHg, P = 0.004) and the median proximal contractile integral (median 215.5 cm•mmHg•s vs 313.5 cm•mmHg•s, P = 0.039), both being lower in the group with pathological OP acid exposure, and the number of contractions with small or large breaks, which were more frequent in the same group. This group also had a larger number of peristaltic contractions with breaks in the 20 mmHg isobaric contour (38.7% vs 15.38%, P < 0.0001). CONCLUSION: In patients with suspected GERD-related extra-esophageal syndromes pathological OP acid exposure was associated with weaker proximal esophageal motility.
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spelling pubmed-50838042016-11-10 Oropharyngeal acid reflux and motility abnormalities of the proximal esophagus Passaretti, Sandro Mazzoleni, Giorgia Vailati, Cristian Testoni, Pier Alberto World J Gastroenterol Prospective Study AIM: To investigate the relationship between pathological oropharyngeal (OP) acid exposure and esophageal motility in patients with extra-esophageal syndromes. METHODS: In this prospective study we enrolled consecutive outpatients with extra-esophageal symptoms suspected to be related to gastroesophageal reflux disease (GERD). We enrolled only patients with a reflux symptom index (RSI) score-higher than 13 and with previous lung, allergy and ear, nose and throat evaluations excluding other specific diagnoses. All patients underwent 24-h OP pH-metry with the Dx probe and esophageal high-resolution manometry (HRM). Patients were divided into two groups on the basis of a normal or pathological pH-metric finding (Ryan Score) and all manometric characteristics of the two groups were compared. RESULTS: We examined 135 patients with chronic extra-esophageal syndromes. Fifty-one were considered eligible for the study. Of these, 42 decided to participate in the protocol. Patients were divided into two groups on the basis of normal or pathological OP acid exposure. All the HRM parameters were compared for the two groups. Significant differences were found in the median upper esophageal sphincter resting pressure (median 71 mmHg vs 126 mmHg, P = 0.004) and the median proximal contractile integral (median 215.5 cm•mmHg•s vs 313.5 cm•mmHg•s, P = 0.039), both being lower in the group with pathological OP acid exposure, and the number of contractions with small or large breaks, which were more frequent in the same group. This group also had a larger number of peristaltic contractions with breaks in the 20 mmHg isobaric contour (38.7% vs 15.38%, P < 0.0001). CONCLUSION: In patients with suspected GERD-related extra-esophageal syndromes pathological OP acid exposure was associated with weaker proximal esophageal motility. Baishideng Publishing Group Inc 2016-10-28 2016-10-28 /pmc/articles/PMC5083804/ /pubmed/27833390 http://dx.doi.org/10.3748/wjg.v22.i40.8991 Text en ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Prospective Study
Passaretti, Sandro
Mazzoleni, Giorgia
Vailati, Cristian
Testoni, Pier Alberto
Oropharyngeal acid reflux and motility abnormalities of the proximal esophagus
title Oropharyngeal acid reflux and motility abnormalities of the proximal esophagus
title_full Oropharyngeal acid reflux and motility abnormalities of the proximal esophagus
title_fullStr Oropharyngeal acid reflux and motility abnormalities of the proximal esophagus
title_full_unstemmed Oropharyngeal acid reflux and motility abnormalities of the proximal esophagus
title_short Oropharyngeal acid reflux and motility abnormalities of the proximal esophagus
title_sort oropharyngeal acid reflux and motility abnormalities of the proximal esophagus
topic Prospective Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083804/
https://www.ncbi.nlm.nih.gov/pubmed/27833390
http://dx.doi.org/10.3748/wjg.v22.i40.8991
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