Methylation Analysis of DNA Mismatch Repair Genes Using DNA Derived from the Peripheral Blood of Patients with Endometrial Cancer: Epimutation in Endometrial Carcinogenesis

Germline mutation of DNA mismatch repair (MMR) genes is a cause of Lynch syndrome. Methylation of MutL homolog 1 (MLH1) and MutS homolog 2 (MSH2) has been detected in peripheral blood cells of patients with colorectal cancer. This methylation is referred to as epimutation. Methylation of these genes...

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Detalles Bibliográficos
Autores principales: Takeda, Takashi, Banno, Kouji, Yanokura, Megumi, Adachi, Masataka, Iijima, Moito, Kunitomi, Haruko, Nakamura, Kanako, Iida, Miho, Nogami, Yuya, Umene, Kiyoko, Masuda, Kenta, Kobayashi, Yusuke, Yamagami, Wataru, Hirasawa, Akira, Tominaga, Eiichiro, Susumu, Nobuyuki, Aoki, Daisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083925/
https://www.ncbi.nlm.nih.gov/pubmed/27754426
http://dx.doi.org/10.3390/genes7100086

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