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Modafinil Dependence and Hypersexuality: A Case Report and Review of the Evidence
Apart from sleep wake disorders, nowadays, modafinil is being prescribed for several psychiatric disorders including depression. Despite being reported as to be having very low abuse potential, cases of modafinil dependence had come to the limelight. In this case report, we describe a 35 year old ma...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean College of Neuropsychopharmacology
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083941/ https://www.ncbi.nlm.nih.gov/pubmed/27776397 http://dx.doi.org/10.9758/cpn.2016.14.4.402 |
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author | Swapnajeet, Sahoo Subodh, BN Gourav, Gupta |
author_facet | Swapnajeet, Sahoo Subodh, BN Gourav, Gupta |
author_sort | Swapnajeet, Sahoo |
collection | PubMed |
description | Apart from sleep wake disorders, nowadays, modafinil is being prescribed for several psychiatric disorders including depression. Despite being reported as to be having very low abuse potential, cases of modafinil dependence had come to the limelight. In this case report, we describe a 35 year old man with bipolar affective disorder while in remission who developed modafinil dependence and later on, had hypersexuality when he increased the dose of modafinil from 400 to 1,000 mg/day. Existing literature suggests that modafinil when taken above prescribed doses can cause many side effects ranging from nausea, vomiting to psychotic exacerbation and mania. However, hypersexuality as a side effect of modafinil overuse is not commonly seen. The exact pathophysiological mechanism of modafinil induced hypersexuality is not clear. Clinicians should be aware of possibility of modafinil leading to dependence and this rare significant side effect of modafinil. |
format | Online Article Text |
id | pubmed-5083941 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Korean College of Neuropsychopharmacology |
record_format | MEDLINE/PubMed |
spelling | pubmed-50839412016-11-01 Modafinil Dependence and Hypersexuality: A Case Report and Review of the Evidence Swapnajeet, Sahoo Subodh, BN Gourav, Gupta Clin Psychopharmacol Neurosci Case Report Apart from sleep wake disorders, nowadays, modafinil is being prescribed for several psychiatric disorders including depression. Despite being reported as to be having very low abuse potential, cases of modafinil dependence had come to the limelight. In this case report, we describe a 35 year old man with bipolar affective disorder while in remission who developed modafinil dependence and later on, had hypersexuality when he increased the dose of modafinil from 400 to 1,000 mg/day. Existing literature suggests that modafinil when taken above prescribed doses can cause many side effects ranging from nausea, vomiting to psychotic exacerbation and mania. However, hypersexuality as a side effect of modafinil overuse is not commonly seen. The exact pathophysiological mechanism of modafinil induced hypersexuality is not clear. Clinicians should be aware of possibility of modafinil leading to dependence and this rare significant side effect of modafinil. Korean College of Neuropsychopharmacology 2016-11 2016-11-30 /pmc/articles/PMC5083941/ /pubmed/27776397 http://dx.doi.org/10.9758/cpn.2016.14.4.402 Text en Copyright © 2016, Korean College of Neuropsychopharmacology This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Swapnajeet, Sahoo Subodh, BN Gourav, Gupta Modafinil Dependence and Hypersexuality: A Case Report and Review of the Evidence |
title | Modafinil Dependence and Hypersexuality: A Case Report and Review of the Evidence |
title_full | Modafinil Dependence and Hypersexuality: A Case Report and Review of the Evidence |
title_fullStr | Modafinil Dependence and Hypersexuality: A Case Report and Review of the Evidence |
title_full_unstemmed | Modafinil Dependence and Hypersexuality: A Case Report and Review of the Evidence |
title_short | Modafinil Dependence and Hypersexuality: A Case Report and Review of the Evidence |
title_sort | modafinil dependence and hypersexuality: a case report and review of the evidence |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083941/ https://www.ncbi.nlm.nih.gov/pubmed/27776397 http://dx.doi.org/10.9758/cpn.2016.14.4.402 |
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