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The Role of Bioactive Dietary Components in Modulating miRNA Expression in Colorectal Cancer

Colorectal cancer is the third most common cancer in the world and considered to be one of the most diet-related types of cancer. Extensive research has been conducted but still the link between diet and colorectal cancer is complex. Recent studies have highlight microRNAs (miRNAs) as key players in...

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Autores principales: Gavrilas, Laura I., Ionescu, Corina, Tudoran, Oana, Lisencu, Cosmin, Balacescu, Ovidiu, Miere, Doina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083978/
https://www.ncbi.nlm.nih.gov/pubmed/27681738
http://dx.doi.org/10.3390/nu8100590
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author Gavrilas, Laura I.
Ionescu, Corina
Tudoran, Oana
Lisencu, Cosmin
Balacescu, Ovidiu
Miere, Doina
author_facet Gavrilas, Laura I.
Ionescu, Corina
Tudoran, Oana
Lisencu, Cosmin
Balacescu, Ovidiu
Miere, Doina
author_sort Gavrilas, Laura I.
collection PubMed
description Colorectal cancer is the third most common cancer in the world and considered to be one of the most diet-related types of cancer. Extensive research has been conducted but still the link between diet and colorectal cancer is complex. Recent studies have highlight microRNAs (miRNAs) as key players in cancer-related pathways in the context of dietary modulation. MicroRNAs are involved in most biological processes related to tumor development and progression; therefore, it is of great interest to understand the underlying mechanisms by which dietary patterns and components influence the expression of these powerful molecules in colorectal cancer. In this review, we discuss relevant dietary patterns in terms of miRNAs modulation in colorectal cancer, as well as bioactive dietary components able to modify gene expression through changes in miRNA expression. Furthermore, we emphasize on protective components such as resveratrol, curcumin, quercetin, α-mangostin, omega-3 fatty acids, vitamin D and dietary fiber, with a focus on the molecular mechanisms in the context of prevention and even treatment. In addition, several bioactive dietary components that have the ability to re-sensitize treatment resistant cells are described.
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spelling pubmed-50839782016-11-01 The Role of Bioactive Dietary Components in Modulating miRNA Expression in Colorectal Cancer Gavrilas, Laura I. Ionescu, Corina Tudoran, Oana Lisencu, Cosmin Balacescu, Ovidiu Miere, Doina Nutrients Review Colorectal cancer is the third most common cancer in the world and considered to be one of the most diet-related types of cancer. Extensive research has been conducted but still the link between diet and colorectal cancer is complex. Recent studies have highlight microRNAs (miRNAs) as key players in cancer-related pathways in the context of dietary modulation. MicroRNAs are involved in most biological processes related to tumor development and progression; therefore, it is of great interest to understand the underlying mechanisms by which dietary patterns and components influence the expression of these powerful molecules in colorectal cancer. In this review, we discuss relevant dietary patterns in terms of miRNAs modulation in colorectal cancer, as well as bioactive dietary components able to modify gene expression through changes in miRNA expression. Furthermore, we emphasize on protective components such as resveratrol, curcumin, quercetin, α-mangostin, omega-3 fatty acids, vitamin D and dietary fiber, with a focus on the molecular mechanisms in the context of prevention and even treatment. In addition, several bioactive dietary components that have the ability to re-sensitize treatment resistant cells are described. MDPI 2016-09-26 /pmc/articles/PMC5083978/ /pubmed/27681738 http://dx.doi.org/10.3390/nu8100590 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gavrilas, Laura I.
Ionescu, Corina
Tudoran, Oana
Lisencu, Cosmin
Balacescu, Ovidiu
Miere, Doina
The Role of Bioactive Dietary Components in Modulating miRNA Expression in Colorectal Cancer
title The Role of Bioactive Dietary Components in Modulating miRNA Expression in Colorectal Cancer
title_full The Role of Bioactive Dietary Components in Modulating miRNA Expression in Colorectal Cancer
title_fullStr The Role of Bioactive Dietary Components in Modulating miRNA Expression in Colorectal Cancer
title_full_unstemmed The Role of Bioactive Dietary Components in Modulating miRNA Expression in Colorectal Cancer
title_short The Role of Bioactive Dietary Components in Modulating miRNA Expression in Colorectal Cancer
title_sort role of bioactive dietary components in modulating mirna expression in colorectal cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083978/
https://www.ncbi.nlm.nih.gov/pubmed/27681738
http://dx.doi.org/10.3390/nu8100590
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