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Plasma Carotenoids, Tocopherols, and Retinol in the Age-Stratified (35–74 Years) General Population: A Cross-Sectional Study in Six European Countries

Blood micronutrient status may change with age. We analyzed plasma carotenoids, α-/γ-tocopherol, and retinol and their associations with age, demographic characteristics, and dietary habits (assessed by a short food frequency questionnaire) in a cross-sectional study of 2118 women and men (age-strat...

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Autores principales: Stuetz, Wolfgang, Weber, Daniela, Dollé, Martijn E. T., Jansen, Eugène, Grubeck-Loebenstein, Beatrix, Fiegl, Simone, Toussaint, Olivier, Bernhardt, Juergen, Gonos, Efstathios S., Franceschi, Claudio, Sikora, Ewa, Moreno-Villanueva, María, Breusing, Nicolle, Grune, Tilman, Bürkle, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084002/
https://www.ncbi.nlm.nih.gov/pubmed/27706032
http://dx.doi.org/10.3390/nu8100614
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author Stuetz, Wolfgang
Weber, Daniela
Dollé, Martijn E. T.
Jansen, Eugène
Grubeck-Loebenstein, Beatrix
Fiegl, Simone
Toussaint, Olivier
Bernhardt, Juergen
Gonos, Efstathios S.
Franceschi, Claudio
Sikora, Ewa
Moreno-Villanueva, María
Breusing, Nicolle
Grune, Tilman
Bürkle, Alexander
author_facet Stuetz, Wolfgang
Weber, Daniela
Dollé, Martijn E. T.
Jansen, Eugène
Grubeck-Loebenstein, Beatrix
Fiegl, Simone
Toussaint, Olivier
Bernhardt, Juergen
Gonos, Efstathios S.
Franceschi, Claudio
Sikora, Ewa
Moreno-Villanueva, María
Breusing, Nicolle
Grune, Tilman
Bürkle, Alexander
author_sort Stuetz, Wolfgang
collection PubMed
description Blood micronutrient status may change with age. We analyzed plasma carotenoids, α-/γ-tocopherol, and retinol and their associations with age, demographic characteristics, and dietary habits (assessed by a short food frequency questionnaire) in a cross-sectional study of 2118 women and men (age-stratified from 35 to 74 years) of the general population from six European countries. Higher age was associated with lower lycopene and α-/β-carotene and higher β-cryptoxanthin, lutein, zeaxanthin, α-/γ-tocopherol, and retinol levels. Significant correlations with age were observed for lycopene (r = −0.248), α-tocopherol (r = 0.208), α-carotene (r = −0.112), and β-cryptoxanthin (r = 0.125; all p < 0.001). Age was inversely associated with lycopene (−6.5% per five-year age increase) and this association remained in the multiple regression model with the significant predictors (covariables) being country, season, cholesterol, gender, smoking status, body mass index (BMI (kg/m(2))), and dietary habits. The positive association of α-tocopherol with age remained when all covariates including cholesterol and use of vitamin supplements were included (1.7% vs. 2.4% per five-year age increase). The association of higher β-cryptoxanthin with higher age was no longer statistically significant after adjustment for fruit consumption, whereas the inverse association of α-carotene with age remained in the fully adjusted multivariable model (−4.8% vs. −3.8% per five-year age increase). We conclude from our study that age is an independent predictor of plasma lycopene, α-tocopherol, and α-carotene.
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spelling pubmed-50840022016-11-01 Plasma Carotenoids, Tocopherols, and Retinol in the Age-Stratified (35–74 Years) General Population: A Cross-Sectional Study in Six European Countries Stuetz, Wolfgang Weber, Daniela Dollé, Martijn E. T. Jansen, Eugène Grubeck-Loebenstein, Beatrix Fiegl, Simone Toussaint, Olivier Bernhardt, Juergen Gonos, Efstathios S. Franceschi, Claudio Sikora, Ewa Moreno-Villanueva, María Breusing, Nicolle Grune, Tilman Bürkle, Alexander Nutrients Article Blood micronutrient status may change with age. We analyzed plasma carotenoids, α-/γ-tocopherol, and retinol and their associations with age, demographic characteristics, and dietary habits (assessed by a short food frequency questionnaire) in a cross-sectional study of 2118 women and men (age-stratified from 35 to 74 years) of the general population from six European countries. Higher age was associated with lower lycopene and α-/β-carotene and higher β-cryptoxanthin, lutein, zeaxanthin, α-/γ-tocopherol, and retinol levels. Significant correlations with age were observed for lycopene (r = −0.248), α-tocopherol (r = 0.208), α-carotene (r = −0.112), and β-cryptoxanthin (r = 0.125; all p < 0.001). Age was inversely associated with lycopene (−6.5% per five-year age increase) and this association remained in the multiple regression model with the significant predictors (covariables) being country, season, cholesterol, gender, smoking status, body mass index (BMI (kg/m(2))), and dietary habits. The positive association of α-tocopherol with age remained when all covariates including cholesterol and use of vitamin supplements were included (1.7% vs. 2.4% per five-year age increase). The association of higher β-cryptoxanthin with higher age was no longer statistically significant after adjustment for fruit consumption, whereas the inverse association of α-carotene with age remained in the fully adjusted multivariable model (−4.8% vs. −3.8% per five-year age increase). We conclude from our study that age is an independent predictor of plasma lycopene, α-tocopherol, and α-carotene. MDPI 2016-09-30 /pmc/articles/PMC5084002/ /pubmed/27706032 http://dx.doi.org/10.3390/nu8100614 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Stuetz, Wolfgang
Weber, Daniela
Dollé, Martijn E. T.
Jansen, Eugène
Grubeck-Loebenstein, Beatrix
Fiegl, Simone
Toussaint, Olivier
Bernhardt, Juergen
Gonos, Efstathios S.
Franceschi, Claudio
Sikora, Ewa
Moreno-Villanueva, María
Breusing, Nicolle
Grune, Tilman
Bürkle, Alexander
Plasma Carotenoids, Tocopherols, and Retinol in the Age-Stratified (35–74 Years) General Population: A Cross-Sectional Study in Six European Countries
title Plasma Carotenoids, Tocopherols, and Retinol in the Age-Stratified (35–74 Years) General Population: A Cross-Sectional Study in Six European Countries
title_full Plasma Carotenoids, Tocopherols, and Retinol in the Age-Stratified (35–74 Years) General Population: A Cross-Sectional Study in Six European Countries
title_fullStr Plasma Carotenoids, Tocopherols, and Retinol in the Age-Stratified (35–74 Years) General Population: A Cross-Sectional Study in Six European Countries
title_full_unstemmed Plasma Carotenoids, Tocopherols, and Retinol in the Age-Stratified (35–74 Years) General Population: A Cross-Sectional Study in Six European Countries
title_short Plasma Carotenoids, Tocopherols, and Retinol in the Age-Stratified (35–74 Years) General Population: A Cross-Sectional Study in Six European Countries
title_sort plasma carotenoids, tocopherols, and retinol in the age-stratified (35–74 years) general population: a cross-sectional study in six european countries
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084002/
https://www.ncbi.nlm.nih.gov/pubmed/27706032
http://dx.doi.org/10.3390/nu8100614
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