Cargando…

The Effect of Vegan Protein-Based Diets on Metabolic Parameters, Expressions of Adiponectin and Its Receptors in Wistar Rats

Vegan protein-based diet has attracted increasing interest in the prevention of metabolic syndrome (MetS). Meanwhile, adiponectin has become a highly potential molecular target in the prevention of MetS. Our study will identify a potential vegan protein diet for the prevention of MetS using rat mode...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Jie-Hua, Song, Jia, Chen, Yan, Ding, Qiang, Peng, Anfang, Mao, Limei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084030/
https://www.ncbi.nlm.nih.gov/pubmed/27763537
http://dx.doi.org/10.3390/nu8100643
_version_ 1782463331080077312
author Chen, Jie-Hua
Song, Jia
Chen, Yan
Ding, Qiang
Peng, Anfang
Mao, Limei
author_facet Chen, Jie-Hua
Song, Jia
Chen, Yan
Ding, Qiang
Peng, Anfang
Mao, Limei
author_sort Chen, Jie-Hua
collection PubMed
description Vegan protein-based diet has attracted increasing interest in the prevention of metabolic syndrome (MetS). Meanwhile, adiponectin has become a highly potential molecular target in the prevention of MetS. Our study will identify a potential vegan protein diet for the prevention of MetS using rat models. Thirty-six Wistar rats were randomly assigned into three groups and given diets containing one of the following proteins for 12 weeks: casein (CAS, control diet), soy protein (SOY), and gluten-soy mixed protein (GSM). Changes in metabolic parameters as well as the expressions of adiponectin and its receptors were identified. Compared to CAS diet, both SOY and GSM diets led to decreases in blood total cholesterol and triglycerides, but only GSM diet led to an increase in HDL-cholesterol; no marked difference was observed in blood glucose in all three groups; HOMA-IR was found lower only in SOY group. Among groups, the order of serum adiponectin level was found as GSM > SOY > CAS. Similar order pattern was also observed in expression of adiponectin in adipose tissue and AdipoR1 mRNA in skeletal muscle. Our results suggested for the first time that, besides SOY diet, GSM diet could also be a possible substitute of animal protein to prevent MetS.
format Online
Article
Text
id pubmed-5084030
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-50840302016-11-01 The Effect of Vegan Protein-Based Diets on Metabolic Parameters, Expressions of Adiponectin and Its Receptors in Wistar Rats Chen, Jie-Hua Song, Jia Chen, Yan Ding, Qiang Peng, Anfang Mao, Limei Nutrients Article Vegan protein-based diet has attracted increasing interest in the prevention of metabolic syndrome (MetS). Meanwhile, adiponectin has become a highly potential molecular target in the prevention of MetS. Our study will identify a potential vegan protein diet for the prevention of MetS using rat models. Thirty-six Wistar rats were randomly assigned into three groups and given diets containing one of the following proteins for 12 weeks: casein (CAS, control diet), soy protein (SOY), and gluten-soy mixed protein (GSM). Changes in metabolic parameters as well as the expressions of adiponectin and its receptors were identified. Compared to CAS diet, both SOY and GSM diets led to decreases in blood total cholesterol and triglycerides, but only GSM diet led to an increase in HDL-cholesterol; no marked difference was observed in blood glucose in all three groups; HOMA-IR was found lower only in SOY group. Among groups, the order of serum adiponectin level was found as GSM > SOY > CAS. Similar order pattern was also observed in expression of adiponectin in adipose tissue and AdipoR1 mRNA in skeletal muscle. Our results suggested for the first time that, besides SOY diet, GSM diet could also be a possible substitute of animal protein to prevent MetS. MDPI 2016-10-18 /pmc/articles/PMC5084030/ /pubmed/27763537 http://dx.doi.org/10.3390/nu8100643 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Jie-Hua
Song, Jia
Chen, Yan
Ding, Qiang
Peng, Anfang
Mao, Limei
The Effect of Vegan Protein-Based Diets on Metabolic Parameters, Expressions of Adiponectin and Its Receptors in Wistar Rats
title The Effect of Vegan Protein-Based Diets on Metabolic Parameters, Expressions of Adiponectin and Its Receptors in Wistar Rats
title_full The Effect of Vegan Protein-Based Diets on Metabolic Parameters, Expressions of Adiponectin and Its Receptors in Wistar Rats
title_fullStr The Effect of Vegan Protein-Based Diets on Metabolic Parameters, Expressions of Adiponectin and Its Receptors in Wistar Rats
title_full_unstemmed The Effect of Vegan Protein-Based Diets on Metabolic Parameters, Expressions of Adiponectin and Its Receptors in Wistar Rats
title_short The Effect of Vegan Protein-Based Diets on Metabolic Parameters, Expressions of Adiponectin and Its Receptors in Wistar Rats
title_sort effect of vegan protein-based diets on metabolic parameters, expressions of adiponectin and its receptors in wistar rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084030/
https://www.ncbi.nlm.nih.gov/pubmed/27763537
http://dx.doi.org/10.3390/nu8100643
work_keys_str_mv AT chenjiehua theeffectofveganproteinbaseddietsonmetabolicparametersexpressionsofadiponectinanditsreceptorsinwistarrats
AT songjia theeffectofveganproteinbaseddietsonmetabolicparametersexpressionsofadiponectinanditsreceptorsinwistarrats
AT chenyan theeffectofveganproteinbaseddietsonmetabolicparametersexpressionsofadiponectinanditsreceptorsinwistarrats
AT dingqiang theeffectofveganproteinbaseddietsonmetabolicparametersexpressionsofadiponectinanditsreceptorsinwistarrats
AT penganfang theeffectofveganproteinbaseddietsonmetabolicparametersexpressionsofadiponectinanditsreceptorsinwistarrats
AT maolimei theeffectofveganproteinbaseddietsonmetabolicparametersexpressionsofadiponectinanditsreceptorsinwistarrats
AT chenjiehua effectofveganproteinbaseddietsonmetabolicparametersexpressionsofadiponectinanditsreceptorsinwistarrats
AT songjia effectofveganproteinbaseddietsonmetabolicparametersexpressionsofadiponectinanditsreceptorsinwistarrats
AT chenyan effectofveganproteinbaseddietsonmetabolicparametersexpressionsofadiponectinanditsreceptorsinwistarrats
AT dingqiang effectofveganproteinbaseddietsonmetabolicparametersexpressionsofadiponectinanditsreceptorsinwistarrats
AT penganfang effectofveganproteinbaseddietsonmetabolicparametersexpressionsofadiponectinanditsreceptorsinwistarrats
AT maolimei effectofveganproteinbaseddietsonmetabolicparametersexpressionsofadiponectinanditsreceptorsinwistarrats