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Vitamin D Status during Pregnancy in a Multi-Ethnic Population-Representative Swedish Cohort

There is currently little information on changes in vitamin D status during pregnancy and its predictors. The aim was to study the determinants of change in vitamin D status during pregnancy and of vitamin D deficiency (<30 nmol/L) in early pregnancy. Blood was drawn in the first (T1) and third t...

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Autores principales: Bärebring, Linnea, Schoenmakers, Inez, Glantz, Anna, Hulthén, Lena, Jagner, Åse, Ellis, Joy, Bärebring, Mattias, Bullarbo, Maria, Augustin, Hanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084041/
https://www.ncbi.nlm.nih.gov/pubmed/27782070
http://dx.doi.org/10.3390/nu8100655
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author Bärebring, Linnea
Schoenmakers, Inez
Glantz, Anna
Hulthén, Lena
Jagner, Åse
Ellis, Joy
Bärebring, Mattias
Bullarbo, Maria
Augustin, Hanna
author_facet Bärebring, Linnea
Schoenmakers, Inez
Glantz, Anna
Hulthén, Lena
Jagner, Åse
Ellis, Joy
Bärebring, Mattias
Bullarbo, Maria
Augustin, Hanna
author_sort Bärebring, Linnea
collection PubMed
description There is currently little information on changes in vitamin D status during pregnancy and its predictors. The aim was to study the determinants of change in vitamin D status during pregnancy and of vitamin D deficiency (<30 nmol/L) in early pregnancy. Blood was drawn in the first (T1) and third trimester (T3). Serum 25-hydroxyvitamin D (25(OH)D) (N = 1985) was analysed by liquid chromatography tandem-mass spectrometry. Season-corrected 25(OH)D was calculated by fitting cosine functions to the data. Mean (standard deviation) 25(OH)D was 64.5(24.5) nmol/L at T1 and 74.6(34.4) at T3. Mean age was 31.3(4.9) years, mean body mass index (BMI) was 24.5(4.2) kg/m(2) and 74% of the women were born in Sweden. Vitamin D deficiency was common among women born in Africa (51%) and Asia (46%) and prevalent in 10% of the whole cohort. Determinants of vitamin D deficiency at T1 were of non-North European origin, and had less sun exposure, lower vitamin D intake and lower age. Season-corrected 25(OH)D increased by 11(23) nmol/L from T1 to T3. The determinants of season-corrected change in 25(OH)D were origin, sun-seeking behaviour, clothing style, dietary vitamin D intake, vitamin D supplementation and recent travel <35° N. In conclusion, season-corrected 25(OH)D concentration increased during pregnancy and depended partly on lifestyle factors. The overall prevalence of vitamin D deficiency was low but common among women born in Africa and Asia. Among them, the determinants of both vitamin D deficiency and change in season-corrected vitamin D status were fewer, indicating a smaller effect of sun exposure.
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spelling pubmed-50840412016-11-01 Vitamin D Status during Pregnancy in a Multi-Ethnic Population-Representative Swedish Cohort Bärebring, Linnea Schoenmakers, Inez Glantz, Anna Hulthén, Lena Jagner, Åse Ellis, Joy Bärebring, Mattias Bullarbo, Maria Augustin, Hanna Nutrients Article There is currently little information on changes in vitamin D status during pregnancy and its predictors. The aim was to study the determinants of change in vitamin D status during pregnancy and of vitamin D deficiency (<30 nmol/L) in early pregnancy. Blood was drawn in the first (T1) and third trimester (T3). Serum 25-hydroxyvitamin D (25(OH)D) (N = 1985) was analysed by liquid chromatography tandem-mass spectrometry. Season-corrected 25(OH)D was calculated by fitting cosine functions to the data. Mean (standard deviation) 25(OH)D was 64.5(24.5) nmol/L at T1 and 74.6(34.4) at T3. Mean age was 31.3(4.9) years, mean body mass index (BMI) was 24.5(4.2) kg/m(2) and 74% of the women were born in Sweden. Vitamin D deficiency was common among women born in Africa (51%) and Asia (46%) and prevalent in 10% of the whole cohort. Determinants of vitamin D deficiency at T1 were of non-North European origin, and had less sun exposure, lower vitamin D intake and lower age. Season-corrected 25(OH)D increased by 11(23) nmol/L from T1 to T3. The determinants of season-corrected change in 25(OH)D were origin, sun-seeking behaviour, clothing style, dietary vitamin D intake, vitamin D supplementation and recent travel <35° N. In conclusion, season-corrected 25(OH)D concentration increased during pregnancy and depended partly on lifestyle factors. The overall prevalence of vitamin D deficiency was low but common among women born in Africa and Asia. Among them, the determinants of both vitamin D deficiency and change in season-corrected vitamin D status were fewer, indicating a smaller effect of sun exposure. MDPI 2016-10-22 /pmc/articles/PMC5084041/ /pubmed/27782070 http://dx.doi.org/10.3390/nu8100655 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bärebring, Linnea
Schoenmakers, Inez
Glantz, Anna
Hulthén, Lena
Jagner, Åse
Ellis, Joy
Bärebring, Mattias
Bullarbo, Maria
Augustin, Hanna
Vitamin D Status during Pregnancy in a Multi-Ethnic Population-Representative Swedish Cohort
title Vitamin D Status during Pregnancy in a Multi-Ethnic Population-Representative Swedish Cohort
title_full Vitamin D Status during Pregnancy in a Multi-Ethnic Population-Representative Swedish Cohort
title_fullStr Vitamin D Status during Pregnancy in a Multi-Ethnic Population-Representative Swedish Cohort
title_full_unstemmed Vitamin D Status during Pregnancy in a Multi-Ethnic Population-Representative Swedish Cohort
title_short Vitamin D Status during Pregnancy in a Multi-Ethnic Population-Representative Swedish Cohort
title_sort vitamin d status during pregnancy in a multi-ethnic population-representative swedish cohort
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084041/
https://www.ncbi.nlm.nih.gov/pubmed/27782070
http://dx.doi.org/10.3390/nu8100655
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