Ubiquitin versus misfolding: The minimal requirements for inclusion body formation

Ubiquitin-containing inclusion bodies are characteristic features of numerous neurodegenerative diseases, but whether ubiquitin plays a functional role in the formation of these protein deposits is unclear. In this issue, Bersuker et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201511024)...

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Detalles Bibliográficos
Autores principales: Dantuma, Nico P., Salomons, Florian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084277/
https://www.ncbi.nlm.nih.gov/pubmed/27114497
http://dx.doi.org/10.1083/jcb.201603095
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author Dantuma, Nico P.
Salomons, Florian A.
author_facet Dantuma, Nico P.
Salomons, Florian A.
author_sort Dantuma, Nico P.
collection PubMed
description Ubiquitin-containing inclusion bodies are characteristic features of numerous neurodegenerative diseases, but whether ubiquitin plays a functional role in the formation of these protein deposits is unclear. In this issue, Bersuker et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201511024) report that protein misfolding without ubiquitylation is sufficient for translocation into inclusion bodies.
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spelling pubmed-50842772016-10-31 Ubiquitin versus misfolding: The minimal requirements for inclusion body formation Dantuma, Nico P. Salomons, Florian A. J Cell Biol Reviews Ubiquitin-containing inclusion bodies are characteristic features of numerous neurodegenerative diseases, but whether ubiquitin plays a functional role in the formation of these protein deposits is unclear. In this issue, Bersuker et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201511024) report that protein misfolding without ubiquitylation is sufficient for translocation into inclusion bodies. The Rockefeller University Press 2016-04-25 /pmc/articles/PMC5084277/ /pubmed/27114497 http://dx.doi.org/10.1083/jcb.201603095 Text en © 2016 Dantuma and Salomons This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Dantuma, Nico P.
Salomons, Florian A.
Ubiquitin versus misfolding: The minimal requirements for inclusion body formation
title Ubiquitin versus misfolding: The minimal requirements for inclusion body formation
title_full Ubiquitin versus misfolding: The minimal requirements for inclusion body formation
title_fullStr Ubiquitin versus misfolding: The minimal requirements for inclusion body formation
title_full_unstemmed Ubiquitin versus misfolding: The minimal requirements for inclusion body formation
title_short Ubiquitin versus misfolding: The minimal requirements for inclusion body formation
title_sort ubiquitin versus misfolding: the minimal requirements for inclusion body formation
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084277/
https://www.ncbi.nlm.nih.gov/pubmed/27114497
http://dx.doi.org/10.1083/jcb.201603095
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