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Skin rash, eosinophilia, and renal impairment in a patient recently started on allopurinol

Allopurinol is a hypoxanthine analog which inhibits xanthine oxidase, it is a widely used medication for the treatment of hyperuricemia and gout. Allopurinol-induced drug-induced rash with eosinophilia and systemic symptoms syndrome is an infrequent, life-threatening adverse reaction of allopurinol...

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Autores principales: Jmeian, Ashraf, Hawatmeh, Amer, Shamoon, Razan, Shamoon, Fayez, Guma, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084589/
https://www.ncbi.nlm.nih.gov/pubmed/27843869
http://dx.doi.org/10.4103/2249-4863.192366
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author Jmeian, Ashraf
Hawatmeh, Amer
Shamoon, Razan
Shamoon, Fayez
Guma, Michael
author_facet Jmeian, Ashraf
Hawatmeh, Amer
Shamoon, Razan
Shamoon, Fayez
Guma, Michael
author_sort Jmeian, Ashraf
collection PubMed
description Allopurinol is a hypoxanthine analog which inhibits xanthine oxidase, it is a widely used medication for the treatment of hyperuricemia and gout. Allopurinol-induced drug-induced rash with eosinophilia and systemic symptoms syndrome is an infrequent, life-threatening adverse reaction of allopurinol therapy that is remarkable for the higher mortality rate with the use of allopurinol than with the use of another agent. We present a case of a 62-year-old male with a history of chronic kidney disease stage 3, hypertension and gout who developed skin rash, eosinophilia, and renal impairment 2 weeks after he was started on allopurinol therapy for gout. Allopurinol was stopped, and the patient was started on steroids. This case emphasizes that although allopurinol is commonly used the drug for the treatment of gout. However, it can be associated with serious life-threatening complications. Therefore, care should be taken when prescribing allopurinol, and it should be prescribed only for the appropriate indications.
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spelling pubmed-50845892016-11-14 Skin rash, eosinophilia, and renal impairment in a patient recently started on allopurinol Jmeian, Ashraf Hawatmeh, Amer Shamoon, Razan Shamoon, Fayez Guma, Michael J Family Med Prim Care Case Report Allopurinol is a hypoxanthine analog which inhibits xanthine oxidase, it is a widely used medication for the treatment of hyperuricemia and gout. Allopurinol-induced drug-induced rash with eosinophilia and systemic symptoms syndrome is an infrequent, life-threatening adverse reaction of allopurinol therapy that is remarkable for the higher mortality rate with the use of allopurinol than with the use of another agent. We present a case of a 62-year-old male with a history of chronic kidney disease stage 3, hypertension and gout who developed skin rash, eosinophilia, and renal impairment 2 weeks after he was started on allopurinol therapy for gout. Allopurinol was stopped, and the patient was started on steroids. This case emphasizes that although allopurinol is commonly used the drug for the treatment of gout. However, it can be associated with serious life-threatening complications. Therefore, care should be taken when prescribing allopurinol, and it should be prescribed only for the appropriate indications. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC5084589/ /pubmed/27843869 http://dx.doi.org/10.4103/2249-4863.192366 Text en Copyright: © Journal of Family Medicine and Primary Care http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Jmeian, Ashraf
Hawatmeh, Amer
Shamoon, Razan
Shamoon, Fayez
Guma, Michael
Skin rash, eosinophilia, and renal impairment in a patient recently started on allopurinol
title Skin rash, eosinophilia, and renal impairment in a patient recently started on allopurinol
title_full Skin rash, eosinophilia, and renal impairment in a patient recently started on allopurinol
title_fullStr Skin rash, eosinophilia, and renal impairment in a patient recently started on allopurinol
title_full_unstemmed Skin rash, eosinophilia, and renal impairment in a patient recently started on allopurinol
title_short Skin rash, eosinophilia, and renal impairment in a patient recently started on allopurinol
title_sort skin rash, eosinophilia, and renal impairment in a patient recently started on allopurinol
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084589/
https://www.ncbi.nlm.nih.gov/pubmed/27843869
http://dx.doi.org/10.4103/2249-4863.192366
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