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Dysregulated Expression of Long Noncoding RNAs in Ovarian Cancer

Ovarian cancer is the leading cause of death among women with gynecologic malignancies. The development and progression of ovarian cancer are complex and a multiple-step process. New biomarker molecules for diagnostic and prognostic are essential for novel therapeutic targets and to extend the survi...

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Detalles Bibliográficos
Autores principales: Zhong, Yancheng, Gao, Dan, He, Shiwei, Shuai, Cijun, Peng, Shuping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084630/
https://www.ncbi.nlm.nih.gov/pubmed/27603915
http://dx.doi.org/10.1097/IGC.0000000000000828
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author Zhong, Yancheng
Gao, Dan
He, Shiwei
Shuai, Cijun
Peng, Shuping
author_facet Zhong, Yancheng
Gao, Dan
He, Shiwei
Shuai, Cijun
Peng, Shuping
author_sort Zhong, Yancheng
collection PubMed
description Ovarian cancer is the leading cause of death among women with gynecologic malignancies. The development and progression of ovarian cancer are complex and a multiple-step process. New biomarker molecules for diagnostic and prognostic are essential for novel therapeutic targets and to extend the survival time of patients with ovarian cancer. Long noncoding RNAs (lncRNAs) are non–protein-coding transcripts longer than 200 nucleotides that have recently been found as key regulators of various biological processes and to be involved in the development and progression of many diseases including cancers. In this review, we summarized the expression pattern of several dysregulated lncRNAs (HOTAIR, H19, XIST, and HOST2) and the functional molecular mechanism of these lncRNAs on the initiation and progression of ovarian cancer. The lncRNAs as biomarkers may be used for current and future clinical diagnosis, therapeutics, and prognosis.
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spelling pubmed-50846302016-11-07 Dysregulated Expression of Long Noncoding RNAs in Ovarian Cancer Zhong, Yancheng Gao, Dan He, Shiwei Shuai, Cijun Peng, Shuping Int J Gynecol Cancer Basic Science Ovarian cancer is the leading cause of death among women with gynecologic malignancies. The development and progression of ovarian cancer are complex and a multiple-step process. New biomarker molecules for diagnostic and prognostic are essential for novel therapeutic targets and to extend the survival time of patients with ovarian cancer. Long noncoding RNAs (lncRNAs) are non–protein-coding transcripts longer than 200 nucleotides that have recently been found as key regulators of various biological processes and to be involved in the development and progression of many diseases including cancers. In this review, we summarized the expression pattern of several dysregulated lncRNAs (HOTAIR, H19, XIST, and HOST2) and the functional molecular mechanism of these lncRNAs on the initiation and progression of ovarian cancer. The lncRNAs as biomarkers may be used for current and future clinical diagnosis, therapeutics, and prognosis. Lippincott Williams & Wilkins 2016-11 2016-09-06 /pmc/articles/PMC5084630/ /pubmed/27603915 http://dx.doi.org/10.1097/IGC.0000000000000828 Text en Copyright © 2016 by IGCS and ESGO This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.
spellingShingle Basic Science
Zhong, Yancheng
Gao, Dan
He, Shiwei
Shuai, Cijun
Peng, Shuping
Dysregulated Expression of Long Noncoding RNAs in Ovarian Cancer
title Dysregulated Expression of Long Noncoding RNAs in Ovarian Cancer
title_full Dysregulated Expression of Long Noncoding RNAs in Ovarian Cancer
title_fullStr Dysregulated Expression of Long Noncoding RNAs in Ovarian Cancer
title_full_unstemmed Dysregulated Expression of Long Noncoding RNAs in Ovarian Cancer
title_short Dysregulated Expression of Long Noncoding RNAs in Ovarian Cancer
title_sort dysregulated expression of long noncoding rnas in ovarian cancer
topic Basic Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084630/
https://www.ncbi.nlm.nih.gov/pubmed/27603915
http://dx.doi.org/10.1097/IGC.0000000000000828
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