Slip slidin’ away of mitosis with CRL2(Zyg11)

The spindle assembly checkpoint arrests mitotic cells by preventing degradation of cyclin B1 by the anaphase-promoting complex/cyclosome, but some cells evade this checkpoint and slip out of mitosis. Balachandran et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201601083) show that the E3 l...

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Detalles Bibliográficos
Autor principal: Brandeis, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084651/
https://www.ncbi.nlm.nih.gov/pubmed/27810907
http://dx.doi.org/10.1083/jcb.201609086
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author Brandeis, Michael
author_facet Brandeis, Michael
author_sort Brandeis, Michael
collection PubMed
description The spindle assembly checkpoint arrests mitotic cells by preventing degradation of cyclin B1 by the anaphase-promoting complex/cyclosome, but some cells evade this checkpoint and slip out of mitosis. Balachandran et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201601083) show that the E3 ligase CRL2(ZYG11) degrades cyclin B1, allowing mitotic slippage.
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spelling pubmed-50846512017-04-24 Slip slidin’ away of mitosis with CRL2(Zyg11) Brandeis, Michael J Cell Biol Commentary The spindle assembly checkpoint arrests mitotic cells by preventing degradation of cyclin B1 by the anaphase-promoting complex/cyclosome, but some cells evade this checkpoint and slip out of mitosis. Balachandran et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201601083) show that the E3 ligase CRL2(ZYG11) degrades cyclin B1, allowing mitotic slippage. The Rockefeller University Press 2016-10-24 /pmc/articles/PMC5084651/ /pubmed/27810907 http://dx.doi.org/10.1083/jcb.201609086 Text en © 2016 Brandeis This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Commentary
Brandeis, Michael
Slip slidin’ away of mitosis with CRL2(Zyg11)
title Slip slidin’ away of mitosis with CRL2(Zyg11)
title_full Slip slidin’ away of mitosis with CRL2(Zyg11)
title_fullStr Slip slidin’ away of mitosis with CRL2(Zyg11)
title_full_unstemmed Slip slidin’ away of mitosis with CRL2(Zyg11)
title_short Slip slidin’ away of mitosis with CRL2(Zyg11)
title_sort slip slidin’ away of mitosis with crl2(zyg11)
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084651/
https://www.ncbi.nlm.nih.gov/pubmed/27810907
http://dx.doi.org/10.1083/jcb.201609086
work_keys_str_mv AT brandeismichael slipslidinawayofmitosiswithcrl2zyg11

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