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Small‐molecule Hedgehog inhibitor attenuates the leukemia‐initiation potential of acute myeloid leukemia cells

Aberrant activation of the Hedgehog signaling pathway has been implicated in the maintenance of leukemia stem cell populations in several model systems. PF‐04449913 (PF‐913) is a selective, small‐molecule inhibitor of Smoothened, a membrane protein that regulates the Hedgehog pathway. However, detai...

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Detalles Bibliográficos
Autores principales:	Fukushima, Nobuaki, Minami, Yosuke, Kakiuchi, Seiji, Kuwatsuka, Yachiyo, Hayakawa, Fumihiko, Jamieson, Catoriona, Kiyoi, Hitoshi, Naoe, Tomoki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084664/ https://www.ncbi.nlm.nih.gov/pubmed/27461445 http://dx.doi.org/10.1111/cas.13019

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