GSK3ß‐dependent dysregulation of neurodevelopment in SPG11‐patient induced pluripotent stem cell model

OBJECTIVE: Mutations in the spastic paraplegia gene 11 (SPG11), encoding spatacsin, cause the most frequent form of autosomal‐recessive complex hereditary spastic paraplegia (HSP) and juvenile‐onset amyotrophic lateral sclerosis (ALS5). When SPG11 is mutated, patients frequently present with spastic...

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Detalles Bibliográficos
Autores principales: Mishra, Himanshu K., Prots, Iryna, Havlicek, Steven, Kohl, Zacharias, Perez‐Branguli, Francesc, Boerstler, Tom, Anneser, Lukas, Minakaki, Georgia, Wend, Holger, Hampl, Martin, Leone, Marina, Brückner, Martina, Klucken, Jochen, Reis, Andre, Boyer, Leah, Schuierer, Gerhard, Behrens, Jürgen, Lampert, Angelika, Engel, Felix B., Gage, Fred H., Winkler, Jürgen, Winner, Beate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084783/
https://www.ncbi.nlm.nih.gov/pubmed/26971897
http://dx.doi.org/10.1002/ana.24633

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