Cargando…
Chemerin Stimulates Vascular Smooth Muscle Cell Proliferation and Carotid Neointimal Hyperplasia by Activating Mitogen-Activated Protein Kinase Signaling
Vascular neointimal hyperplasia and remodeling arising from local inflammation are characteristic pathogeneses of proliferative cardiovascular diseases, such as atherosclerosis and post angioplasty restenosis. The molecular mechanisms behind these pathological processes have not been fully determine...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085037/ https://www.ncbi.nlm.nih.gov/pubmed/27792753 http://dx.doi.org/10.1371/journal.pone.0165305 |
_version_ | 1782463490739404800 |
---|---|
author | Xiong, Wei Luo, Yu Wu, Lin Liu, Feng Liu, Huadong Li, Jianghua Liao, Bihong Dong, Shaohong |
author_facet | Xiong, Wei Luo, Yu Wu, Lin Liu, Feng Liu, Huadong Li, Jianghua Liao, Bihong Dong, Shaohong |
author_sort | Xiong, Wei |
collection | PubMed |
description | Vascular neointimal hyperplasia and remodeling arising from local inflammation are characteristic pathogeneses of proliferative cardiovascular diseases, such as atherosclerosis and post angioplasty restenosis. The molecular mechanisms behind these pathological processes have not been fully determined. The adipokine chemerin is associated with obesity, metabolism, and control of inflammation. Recently, chemerin has gained increased attention as it was found to play a critical role in the development of cardiovascular diseases. In this study, we investigated the effects of chemerin on the regulation of vascular smooth muscle cells and carotid neointimal formation after angioplasty. We found that circulating chemerin levels increased after carotid balloon injury, and that knockdown of chemerin significantly inhibited the proliferative aspects of vascular smooth muscle cells induced by platelet-derived growth factor-BB and pro-inflammatory chemokines in vitro as well as prohibited carotid neointimal hyperplasia and pro-inflammatory chemokines in vivo after angioplasty. Additionally, inhibition of chemerin down-regulated the expression of several proteins, including phosphorylated p38 mitogen-activated protein kinase, phosphorylated extracellular signal regulated kinase 1/2, nuclear factor-kappa B p65, and proliferation cell nuclear antigen. The novel finding of this study is that chemerin stimulated vascular smooth muscle cells proliferation and carotid intimal hyperplasia through activation of the mitogen-activated protein kinase signaling pathway, which may lead to vascular inflammation and remodeling, and is relevant to proliferative cardiovascular diseases. |
format | Online Article Text |
id | pubmed-5085037 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-50850372016-11-04 Chemerin Stimulates Vascular Smooth Muscle Cell Proliferation and Carotid Neointimal Hyperplasia by Activating Mitogen-Activated Protein Kinase Signaling Xiong, Wei Luo, Yu Wu, Lin Liu, Feng Liu, Huadong Li, Jianghua Liao, Bihong Dong, Shaohong PLoS One Research Article Vascular neointimal hyperplasia and remodeling arising from local inflammation are characteristic pathogeneses of proliferative cardiovascular diseases, such as atherosclerosis and post angioplasty restenosis. The molecular mechanisms behind these pathological processes have not been fully determined. The adipokine chemerin is associated with obesity, metabolism, and control of inflammation. Recently, chemerin has gained increased attention as it was found to play a critical role in the development of cardiovascular diseases. In this study, we investigated the effects of chemerin on the regulation of vascular smooth muscle cells and carotid neointimal formation after angioplasty. We found that circulating chemerin levels increased after carotid balloon injury, and that knockdown of chemerin significantly inhibited the proliferative aspects of vascular smooth muscle cells induced by platelet-derived growth factor-BB and pro-inflammatory chemokines in vitro as well as prohibited carotid neointimal hyperplasia and pro-inflammatory chemokines in vivo after angioplasty. Additionally, inhibition of chemerin down-regulated the expression of several proteins, including phosphorylated p38 mitogen-activated protein kinase, phosphorylated extracellular signal regulated kinase 1/2, nuclear factor-kappa B p65, and proliferation cell nuclear antigen. The novel finding of this study is that chemerin stimulated vascular smooth muscle cells proliferation and carotid intimal hyperplasia through activation of the mitogen-activated protein kinase signaling pathway, which may lead to vascular inflammation and remodeling, and is relevant to proliferative cardiovascular diseases. Public Library of Science 2016-10-28 /pmc/articles/PMC5085037/ /pubmed/27792753 http://dx.doi.org/10.1371/journal.pone.0165305 Text en © 2016 Xiong et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Xiong, Wei Luo, Yu Wu, Lin Liu, Feng Liu, Huadong Li, Jianghua Liao, Bihong Dong, Shaohong Chemerin Stimulates Vascular Smooth Muscle Cell Proliferation and Carotid Neointimal Hyperplasia by Activating Mitogen-Activated Protein Kinase Signaling |
title | Chemerin Stimulates Vascular Smooth Muscle Cell Proliferation and Carotid Neointimal Hyperplasia by Activating Mitogen-Activated Protein Kinase Signaling |
title_full | Chemerin Stimulates Vascular Smooth Muscle Cell Proliferation and Carotid Neointimal Hyperplasia by Activating Mitogen-Activated Protein Kinase Signaling |
title_fullStr | Chemerin Stimulates Vascular Smooth Muscle Cell Proliferation and Carotid Neointimal Hyperplasia by Activating Mitogen-Activated Protein Kinase Signaling |
title_full_unstemmed | Chemerin Stimulates Vascular Smooth Muscle Cell Proliferation and Carotid Neointimal Hyperplasia by Activating Mitogen-Activated Protein Kinase Signaling |
title_short | Chemerin Stimulates Vascular Smooth Muscle Cell Proliferation and Carotid Neointimal Hyperplasia by Activating Mitogen-Activated Protein Kinase Signaling |
title_sort | chemerin stimulates vascular smooth muscle cell proliferation and carotid neointimal hyperplasia by activating mitogen-activated protein kinase signaling |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085037/ https://www.ncbi.nlm.nih.gov/pubmed/27792753 http://dx.doi.org/10.1371/journal.pone.0165305 |
work_keys_str_mv | AT xiongwei chemerinstimulatesvascularsmoothmusclecellproliferationandcarotidneointimalhyperplasiabyactivatingmitogenactivatedproteinkinasesignaling AT luoyu chemerinstimulatesvascularsmoothmusclecellproliferationandcarotidneointimalhyperplasiabyactivatingmitogenactivatedproteinkinasesignaling AT wulin chemerinstimulatesvascularsmoothmusclecellproliferationandcarotidneointimalhyperplasiabyactivatingmitogenactivatedproteinkinasesignaling AT liufeng chemerinstimulatesvascularsmoothmusclecellproliferationandcarotidneointimalhyperplasiabyactivatingmitogenactivatedproteinkinasesignaling AT liuhuadong chemerinstimulatesvascularsmoothmusclecellproliferationandcarotidneointimalhyperplasiabyactivatingmitogenactivatedproteinkinasesignaling AT lijianghua chemerinstimulatesvascularsmoothmusclecellproliferationandcarotidneointimalhyperplasiabyactivatingmitogenactivatedproteinkinasesignaling AT liaobihong chemerinstimulatesvascularsmoothmusclecellproliferationandcarotidneointimalhyperplasiabyactivatingmitogenactivatedproteinkinasesignaling AT dongshaohong chemerinstimulatesvascularsmoothmusclecellproliferationandcarotidneointimalhyperplasiabyactivatingmitogenactivatedproteinkinasesignaling |