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High-Accuracy HLA Type Inference from Whole-Genome Sequencing Data Using Population Reference Graphs
Genetic variation at the Human Leucocyte Antigen (HLA) genes is associated with many autoimmune and infectious disease phenotypes, is an important element of the immunological distinction between self and non-self, and shapes immune epitope repertoires. Determining the allelic state of the HLA genes...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085092/ https://www.ncbi.nlm.nih.gov/pubmed/27792722 http://dx.doi.org/10.1371/journal.pcbi.1005151 |