Cargando…

β2-spectrin depletion impairs DNA damage repair

β2-Spectrin (β2SP/SPTBN1, gene SPTBN1) is a key TGF-β/SMAD3/4 adaptor and transcriptional cofactor that regulates TGF-β signaling and can contribute to liver cancer development. Here we report that cells deficient in β2-Spectrin (β2SP) are moderately sensitive to ionizing radiation (IR) and extremel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Horikoshi, Nobuo, Pandita, Raj K., Mujoo, Kalpana, Hambarde, Shashank, Sharma, Dharmendra, Mattoo, Abid R., Chakraborty, Sharmistha, Charaka, Vijaya, Hunt, Clayton R., Pandita, Tej K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Priority Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085102/ https://www.ncbi.nlm.nih.gov/pubmed/27248179 http://dx.doi.org/10.18632/oncotarget.9677

Ejemplares similares

SMARCAD1 Phosphorylation and Ubiquitination Are Required for Resection during DNA Double-Strand Break Repair
por: Chakraborty, Sharmistha, et al.
Publicado: (2018)

Nuclear functions of β2-Spectrin in genomic stability
por: Mujoo, Kalpana, et al.
Publicado: (2016)

Pre-existing H4K16ac levels in euchromatin drive DNA repair by homologous recombination in S-phase
por: Horikoshi, Nobuo, et al.
Publicado: (2019)

Differentiation of Human Induced Pluripotent or Embryonic Stem Cells Decreases the DNA Damage Repair by Homologous Recombination
por: Mujoo, Kalpana, et al.
Publicado: (2017)

Heat-induced SIRT1-mediated H4K16ac deacetylation impairs resection and SMARCAD1 recruitment to double strand breaks
por: Chakraborty, Sharmistha, et al.
Publicado: (2022)

Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes
por: Chakraborty, Anirban, et al.
Publicado: (2016)

Chromatin modifications and the DNA damage response to ionizing radiation
por: Kumar, Rakesh, et al.
Publicado: (2013)

Genome-wide distribution of histone H4 Lysine 16 acetylation sites and their relationship to gene expression
por: Horikoshi, Nobuo, et al.
Publicado: (2013)

Emerging therapeutic targets in esophageal adenocarcinoma
por: Gaur, Puja, et al.
Publicado: (2016)

Role of Histone Methylation in Maintenance of Genome Integrity
por: Mushtaq, Arjamand, et al.
Publicado: (2021)

E2FBP1 antagonizes the p16(INK4A)-Rb tumor suppressor machinery for growth suppression and cellular senescence by regulating promyelocytic leukemia protein stability
por: Fukuyo, Yayoi, et al.
Publicado: (2011)

Erratum: miR-15a/miR-16 down-regulates BMI1, impacting Ub-H2A mediated DNA repair and breast cancer cell sensitivity to doxorubicin
por: Patel, Nibedita, et al.
Publicado: (2017)

miR-15a/miR-16 down-regulates BMI1, impacting Ub-H2A mediated DNA repair and breast cancer cell sensitivity to doxorubicin
por: Patel, Nibedita, et al.
Publicado: (2017)

Caspase-2 regulates S-phase cell cycle events to protect from DNA damage accumulation independent of apoptosis
por: Boice, Ashley G., et al.
Publicado: (2021)

ATM Functions at the Peroxisome to Induce Pexophagy in Response to ROS
por: Zhang, Jiangwei, et al.
Publicado: (2015)

Cellular Senescence as a Brake or Accelerator for Oncogenic Transformation and Role in Lymphatic Metastasis
por: Banerjee, Priyanka, et al.
Publicado: (2023)

Transcription regulation of CDKN1A (p21/CIP1/WAF1) by TRF2 is epigenetically controlled through the REST repressor complex
por: Hussain, Tabish, et al.
Publicado: (2017)

Chromatin remodeling finds its place in the DNA double-strand break response
por: Pandita, Tej K., et al.
Publicado: (2009)

Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks
por: Bolderson, Emma, et al.
Publicado: (2014)

Comparison of SARS-CoV-2 RT-PCR on a high-throughput molecular diagnostic platform and the cobas SARS-CoV-2 test for the diagnostic of COVID-19 on various clinical samples
por: Opota, Onya, et al.
Publicado: (2020)

Meta-inflammation and cardiometabolic disease in obesity: Can heat therapy help?
por: Ely, Brett R., et al.
Publicado: (2017)

Release of spectrin-free vesicles from human erythrocytes during ATP depletion: 1. characterization of spectrin-free vesicles
por: Lutz, HU, et al.
Publicado: (1977)

Role of Transposable Elements in Genome Stability: Implications for Health and Disease
por: Bhat, Audesh, et al.
Publicado: (2022)

Depletion of transmembrane mucin 4 (Muc4) alters intestinal homeostasis in a genetically engineered mouse model of colorectal cancer
por: Pothuraju, Ramesh, et al.
Publicado: (2022)

Breakthroughs and Applications of Organ-on-a-Chip Technology
por: Koyilot, Mufeeda C., et al.
Publicado: (2022)

Targeting multidrug-resistant ovarian cancer through estrogen receptor α dependent ATP depletion caused by hyperactivation of the unfolded protein response
por: Zheng, Xiaobin, et al.
Publicado: (2016)

Structurally diverse c-Myc inhibitors share a common mechanism of action involving ATP depletion
por: Wang, Huabo, et al.
Publicado: (2015)

Macrophage depletion through colony stimulating factor 1 receptor pathway blockade overcomes adaptive resistance to anti-VEGF therapy
por: Lyons, Yasmin A., et al.
Publicado: (2017)

Lymphocyte-depleting chemotherapy for aggressive hematologic malignancies in two patients with positive SARS-CoV-2 PCR
por: Pelcovits, Ari, et al.
Publicado: (2021)

Reversible hemifacial spasm due to neurocysticercosis
por: Razdan, Sushil, et al.
Publicado: (2009)

Omics Technology for the Promotion of Nutraceuticals and Functional Foods
por: Pandita, Deepu, et al.
Publicado: (2022)

Bilateral sternoclavicular joint tubercular cold abscess
por: Pandita, K. K., et al.
Publicado: (2010)

Aurora kinase B dependent phosphorylation of 53BP1 is required for resolving merotelic kinetochore-microtubule attachment errors during mitosis
por: Wang, Haibo, et al.
Publicado: (2017)

Spectrin functions upstream of ankyrin in a spectrin cytoskeleton assembly pathway
por: Das, Amlan, et al.
Publicado: (2006)

Tip60-mediated acetylation activates transcription independent apoptotic activity of Abl
por: Jiang, Zhihua, et al.
Publicado: (2011)

Promoter-proximal transcription factor binding is transcriptionally active when coupled with nucleosome repositioning in immediate vicinity
por: Yadav, Vinod Kumar, et al.
Publicado: (2014)

Spectrin is peripheral
por: Bonetta, Laura
Publicado: (2005)

The heat is on: Molecular mechanisms of drug-induced hyperthermia
por: Dao, Christine K, et al.
Publicado: (2014)

The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3’-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis
por: Chatterjee, Arpita, et al.
Publicado: (2015)

Occupational heat stress in Australian workplaces
por: Jay, Ollie, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_018qa6u976thufmieg3jrs11al