Targeting hypoxic microenvironment of pancreatic xenografts with the hypoxia-activated prodrug TH-302

Previous reports have suggested that the hypoxic microenvironment provides a niche that supports tumor stem cells, and that this might explain clinical observations linking hypoxia to metastasis. To test this, we examined the effects of a hypoxia-activated prodrug, TH-302, on the tumor-initiating ce...

Descripción completa

Detalles Bibliográficos
Autores principales: Lohse, Ines, Rasowski, Joanna, Cao, Pinjiang, Pintilie, Melania, Do, Trevor, Tsao, Ming-Sound, Hill, Richard P., Hedley, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085103/
https://www.ncbi.nlm.nih.gov/pubmed/27248663
http://dx.doi.org/10.18632/oncotarget.9654

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085103/
https://www.ncbi.nlm.nih.gov/pubmed/27248663
http://dx.doi.org/10.18632/oncotarget.9654

Ejemplares similares