Novel CD7-specific nanobody-based immunotoxins potently enhanced apoptosis of CD7-positive malignant cells

Various CD7-targeting immunotoxins have been tested for its potential in treating CD7+ malignant patients but none of those immunotoxins was approved clinically because of lacking enough efficacy and safety. Here we successfully constructed the monovalent and bivalent CD7 nanobody-based immunotoxins...

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Detalles Bibliográficos
Autores principales: Tang, Jinle, Li, Jialu, Zhu, Xuejun, Yu, Yuan, Chen, Dan, Yuan, Lei, Gu, Zhenyang, Zhang, Xingding, Qi, Lin, Gong, Zhishu, Jiang, Pengjun, Yu, Juhua, Meng, Huimin, An, Gangli, Zheng, Huyong, Yang, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085138/
https://www.ncbi.nlm.nih.gov/pubmed/27083001
http://dx.doi.org/10.18632/oncotarget.8710

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