Trk inhibition reduces cell proliferation and potentiates the effects of chemotherapeutic agents in Ewing sarcoma

Ewing sarcoma (ES) is a highly aggressive pediatric cancer that may arise from neuronal precursors. Neurotrophins stimulate neuronal devlopment and plasticity. Here, we found that neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), as well as their receptors (TrkA a...

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Detalles Bibliográficos
Autores principales: Heinen, Tiago Elias, dos Santos, Rafael Pereira, da Rocha, Amanda, dos Santos, Michel Pinheiro, da Costa Lopez, Patrícia Luciana, Filho, Marco Aurélio Silva, Souza, Bárbara Kunzler, da Rosa Rivero, Luís Fernando, Becker, Ricardo Gehrke, Gregianin, Lauro José, Brunetto, Algemir Lunardi, Brunetto, André Tesainer, de Farias, Caroline Brunetto, Roesler, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085195/
https://www.ncbi.nlm.nih.gov/pubmed/27145455
http://dx.doi.org/10.18632/oncotarget.8992

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