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SOX2 functions as a molecular rheostat to control the growth, tumorigenicity and drug responses of pancreatic ductal adenocarcinoma cells

Pancreatic ductal adenocarcinoma (PDAC) is a highly deadly malignancy. Expression of the stem cell transcription factor SOX2 increases during progression of PDAC. Knockdown of SOX2 in PDAC cell lines decreases growth in vitro; whereas, stable overexpression of SOX2 in one PDAC cell line reportedly i...

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Detalles Bibliográficos
Autores principales:	Wuebben, Erin L., Wilder, Phillip J., Cox, Jesse L., Grunkemeyer, James A., Caffrey, Thomas, Hollingsworth, Michael A., Rizzino, Angie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085197/ https://www.ncbi.nlm.nih.gov/pubmed/27145457 http://dx.doi.org/10.18632/oncotarget.8994

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