Cargando…

Nobiletin inhibits human osteosarcoma cells metastasis by blocking ERK and JNK-mediated MMPs expression

Nobiletin, a polymethoxyflavone, has a few pharmacological activities, including anti-inflammation and anti-cancer effects. However, its effect on human osteosarcoma progression remains uninvestigated. Therefore, we examined the effectiveness of nobiletin against cellular metastasis of human osteosa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cheng, Hsin-Lin, Hsieh, Ming-Ju, Yang, Jia-Sin, Lin, Chiao-Wen, Lue, Ko-Haung, Lu, Ko-Hsiu, Yang, Shun-Fa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085222/ https://www.ncbi.nlm.nih.gov/pubmed/27144433 http://dx.doi.org/10.18632/oncotarget.9106

Ejemplares similares

Zoledronate blocks geranylgeranylation not farnesylation to suppress human osteosarcoma U2OS cells metastasis by EMT via Rho A activation and FAK-inhibited JNK and p38 pathways
por: Cheng, Hsin-Lin, et al.
Publicado: (2016)

Lipocalin-2 Inhibits Osteosarcoma Cell Metastasis by Suppressing MET Expression via the MEK–ERK Pathway
por: Lu, Ko-Hsiu, et al.
Publicado: (2021)

Niclosamide Suppresses Migration and Invasion of Human Osteosarcoma Cells by Repressing TGFBI Expression via the ERK Signaling Pathway
por: Yeh, Liang-Tsai, et al.
Publicado: (2022)

HO-3867 Induces Apoptosis via the JNK Signaling Pathway in Human Osteosarcoma Cells
por: Lu, Peace Wun-Ang, et al.
Publicado: (2022)

CLEFMA Activates the Extrinsic and Intrinsic Apoptotic Processes through JNK1/2 and p38 Pathways in Human Osteosarcoma Cells
por: Yang, Jia-Sin, et al.
Publicado: (2019)

Tomatidine Represses Invasion and Migration of Human Osteosarcoma U2OS and HOS Cells by Suppression of Presenilin 1 and c-Raf–MEK–ERK Pathway
por: Hsieh, Min-Hong, et al.
Publicado: (2020)

GO-Y078, a Curcumin Analog, Induces Both Apoptotic Pathways in Human Osteosarcoma Cells via Activation of JNK and p38 Signaling
por: Lu, Peace Wun-Ang, et al.
Publicado: (2021)

Molecular and Cellular Mechanisms of Melatonin in Osteosarcoma
por: Lu, Ko-Hsiu, et al.
Publicado: (2019)

Curcumin and its Analogs and Carriers: Potential Therapeutic Strategies for Human Osteosarcoma
por: Lu, Ko-Hsiu, et al.
Publicado: (2023)

Aurora-B Promotes Osteosarcoma Cell Growth and Metastasis Through Activation of the NPM1/ERK/NF-κβ/MMPs Axis
por: Song, Honghai, et al.
Publicado: (2020)

Apoptotic effect and cell arrest of deoxyshikonin in human osteosarcoma cells through the p38 pathway
por: Hsieh, Ming‐Chang, et al.
Publicado: (2023)

Licochalcone A-Induced Apoptosis Through the Activation of p38MAPK Pathway Mediated Mitochondrial Pathways of Apoptosis in Human Osteosarcoma Cells In Vitro and In Vivo
por: Lin, Renn-Chia, et al.
Publicado: (2019)

Potential Antimetastatic Effect of Timosaponin AIII against Human Osteosarcoma Cells through Regulating the Integrin/FAK/Cofilin Axis
por: Hsieh, Yi-Hsien, et al.
Publicado: (2021)

Metastasis-associated gene MAPK15 promotes the migration and invasion of osteosarcoma cells via the c-Jun/MMPs pathway
por: Su, Zexin, et al.
Publicado: (2020)

Curcumin Analogue L48H37 Suppresses Human Osteosarcoma U2OS and MG-63 Cells’ Migration and Invasion in Culture by Inhibition of uPA via the JAK/STAT Signaling Pathway
por: Lu, Ko-Hsiu, et al.
Publicado: (2020)

Morusin Suppresses Cancer Cell Invasion and MMP-2 Expression through ERK Signaling in Human Nasopharyngeal Carcinoma
por: Huang, Cheng-Chen, et al.
Publicado: (2020)

Effect of Nobiletin on Experimental Model of Epilepsy
por: Yang, Baowang, et al.
Publicado: (2018)

Kaempferol Reduces Matrix Metalloproteinase-2 Expression by Down-Regulating ERK1/2 and the Activator Protein-1 Signaling Pathways in Oral Cancer Cells
por: Lin, Chiao-Wen, et al.
Publicado: (2013)

Nobiletin Alleviates Ferroptosis-Associated Renal Injury, Inflammation, and Fibrosis in a Unilateral Ureteral Obstruction Mouse Model
por: Lo, Yi-Hsin, et al.
Publicado: (2022)

Dehydrocrenatidine extracted from Picrasma quassioides induces the apoptosis of nasopharyngeal carcinoma cells through the JNK and ERK signaling pathways
por: Hsieh, Ming-Chang, et al.
Publicado: (2021)

MBIP (MAP3K12 binding inhibitory protein) drives NSCLC metastasis by JNK-dependent activation of MMPs
por: Ochieng, Joshua Kapere, et al.
Publicado: (2020)

Nobiletin ameliorates cardiac impairment and alleviates cardiac remodeling after acute myocardial infarction in rats via JNK regulation
por: Liu, Zumei, et al.
Publicado: (2021)

Curcumin analog HO‐3867 triggers apoptotic pathways through activating JNK1/2 signalling in human oral squamous cell carcinoma cells
por: Chen, Chi‐Wei, et al.
Publicado: (2022)

Terminalia catappa attenuates urokinase-type plasminogen activator expression through Erk pathways in Hepatocellular carcinoma
por: Yeh, Chao-Bin, et al.
Publicado: (2014)

MicroRNAs in the Regulation of MMPs and Metastasis
por: Abba, Mohammed, et al.
Publicado: (2014)

Magnolol Triggers Caspase-Mediated Apoptotic Cell Death in Human Oral Cancer Cells through JNK1/2 and p38 Pathways
por: Chen, Yi-Tzu, et al.
Publicado: (2021)

Matrix Metalloproteinases (MMPs) and Inhibitors of MMPs in the Avian Reproductive System: An Overview
por: Hrabia, Anna
Publicado: (2021)

Extracts of Artocarpus communis Decrease α-Melanocyte Stimulating Hormone-Induced Melanogenesis through Activation of ERK and JNK Signaling Pathways
por: Fu, Yi-Tzu, et al.
Publicado: (2014)

Impact of Interleukin-18 Polymorphisms -607A/C and -137G/C on Oral Cancer Occurrence and Clinical Progression
por: Tsai, Hsiu-Ting, et al.
Publicado: (2013)

The Multifunctional Effects of Nobiletin and Its Metabolites In Vivo and In Vitro
por: Huang, Hao, et al.
Publicado: (2016)

MMPs rearrange DNA
por: LeBrasseur, Nicole
Publicado: (2005)

Inhibition of BUB1 suppresses tumorigenesis of osteosarcoma via blocking of PI3K/Akt and ERK pathways
por: Huang, Zhen, et al.
Publicado: (2021)

Lipocalin 2 Reduces MET Levels by Inhibiting MEK/ERK Signaling to Inhibit Nasopharyngeal Carcinoma Cell Migration
por: Li, Ju-Pi, et al.
Publicado: (2022)

Effects of glycyrrhizin on the pharmacokinetics of nobiletin in rats and its potential mechanism
por: Wang, Hao, et al.
Publicado: (2020)

Nobiletin Exhibits Neuroprotective Effects against Mitochondrial Complex I Inhibition via Regulating Apoptotic Signaling
por: Amarsanaa, Khulan, et al.
Publicado: (2021)

Inhibition of cathepsin S confers sensitivity to methyl protodioscin in oral cancer cells via activation of p38 MAPK/JNK signaling pathways
por: Hsieh, Ming-Ju, et al.
Publicado: (2017)

Sulforaphane suppresses oral cancer cell migration by regulating cathepsin S expression
por: Chen, Chang-Tai, et al.
Publicado: (2018)

Pharmacological actions of nobiletin in the modulation of platelet function
por: Vaiyapuri, Sakthivel, et al.
Publicado: (2015)

Transdermal delivery of nobiletin using ionic liquids
por: Hattori, Tadashi, et al.
Publicado: (2019)

Nobiletin Delays Aging and Enhances Stress Resistance of Caenorhabditis elegans
por: Yang, Xueyan, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_mt7mcssdqol1pqfeg2v69dtavd