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Reduction in promotor methylation utilizing EGCG (epigallocatechin-3-gallate) restores RXRα expression in human colon cancer cells

Silencing of regulatory genes through hypermethylation of CpG islands is an important mechanism in tumorigenesis. In colon cancer, RXRα, an important dimerization partner with other nuclear transcription factors, is silenced through this mechanism. We previously found that colon tumors in Apc(Min/+)...

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Detalles Bibliográficos
Autores principales:	Morris, Jay, Moseley, Vondina R., Cabang, April B., Coleman, Katie, Wei, Wei, Garrett-Mayer, Elizabeth, Wargovich, Michael J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085231/ https://www.ncbi.nlm.nih.gov/pubmed/27167203 http://dx.doi.org/10.18632/oncotarget.9204

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