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Ascorbate availability affects tumor implantation-take rate and increases tumor rejection in Gulo(−/−) mice

In solid tumors, HIF1 upregulates the expression of hundreds of genes involved in cell survival, tumor growth, and adaptation to the hypoxic microenvironment. HIF1 stabilization and activity are suppressed by prolyl and asparagine hydroxylases, which require oxygen as a substrate and ascorbate as a...

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Detalles Bibliográficos
Autores principales:	Campbell, Elizabeth J, Vissers, Margreet CM, Dachs, Gabi U
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2016
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085285/ https://www.ncbi.nlm.nih.gov/pubmed/27800507 http://dx.doi.org/10.2147/HP.S103088

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