Structure of NS3 helicase from Zika virus

The Zika virus has emerged as a pathogen of major health concern. We present a high-resolution (1.62Å) crystal structure of the RNA helicase from the French Polynesia strain. The structure is similar to that of the RNA helicase from Dengue virus, with variability in the conformations of loops typica...

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Detalles Bibliográficos
Autores principales: Jain, Rinku, Coloma, Javier, García-Sastre, Adolfo, Aggarwal, Aneel K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085289/
https://www.ncbi.nlm.nih.gov/pubmed/27399257
http://dx.doi.org/10.1038/nsmb.3258
Descripción
Sumario:The Zika virus has emerged as a pathogen of major health concern. We present a high-resolution (1.62Å) crystal structure of the RNA helicase from the French Polynesia strain. The structure is similar to that of the RNA helicase from Dengue virus, with variability in the conformations of loops typically involved in ATP and RNA binding. We identify druggable “hotspots” that are well-suited for in-silico and/or fragment-based high throughput drug discovery.

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