Structure of NS3 helicase from Zika virus

The Zika virus has emerged as a pathogen of major health concern. We present a high-resolution (1.62Å) crystal structure of the RNA helicase from the French Polynesia strain. The structure is similar to that of the RNA helicase from Dengue virus, with variability in the conformations of loops typica...

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Autores principales: Jain, Rinku, Coloma, Javier, García-Sastre, Adolfo, Aggarwal, Aneel K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085289/
https://www.ncbi.nlm.nih.gov/pubmed/27399257
http://dx.doi.org/10.1038/nsmb.3258
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author Jain, Rinku
Coloma, Javier
García-Sastre, Adolfo
Aggarwal, Aneel K.
author_facet Jain, Rinku
Coloma, Javier
García-Sastre, Adolfo
Aggarwal, Aneel K.
author_sort Jain, Rinku
collection PubMed
description The Zika virus has emerged as a pathogen of major health concern. We present a high-resolution (1.62Å) crystal structure of the RNA helicase from the French Polynesia strain. The structure is similar to that of the RNA helicase from Dengue virus, with variability in the conformations of loops typically involved in ATP and RNA binding. We identify druggable “hotspots” that are well-suited for in-silico and/or fragment-based high throughput drug discovery.
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spelling pubmed-50852892017-01-11 Structure of NS3 helicase from Zika virus Jain, Rinku Coloma, Javier García-Sastre, Adolfo Aggarwal, Aneel K. Nat Struct Mol Biol Article The Zika virus has emerged as a pathogen of major health concern. We present a high-resolution (1.62Å) crystal structure of the RNA helicase from the French Polynesia strain. The structure is similar to that of the RNA helicase from Dengue virus, with variability in the conformations of loops typically involved in ATP and RNA binding. We identify druggable “hotspots” that are well-suited for in-silico and/or fragment-based high throughput drug discovery. 2016-07-11 2016-08 /pmc/articles/PMC5085289/ /pubmed/27399257 http://dx.doi.org/10.1038/nsmb.3258 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Jain, Rinku
Coloma, Javier
García-Sastre, Adolfo
Aggarwal, Aneel K.
Structure of NS3 helicase from Zika virus
title Structure of NS3 helicase from Zika virus
title_full Structure of NS3 helicase from Zika virus
title_fullStr Structure of NS3 helicase from Zika virus
title_full_unstemmed Structure of NS3 helicase from Zika virus
title_short Structure of NS3 helicase from Zika virus
title_sort structure of ns3 helicase from zika virus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085289/
https://www.ncbi.nlm.nih.gov/pubmed/27399257
http://dx.doi.org/10.1038/nsmb.3258
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