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Phosphorylation of the pyruvate dehydrogenase complex precedes HIF-1-mediated effects and pyruvate dehydrogenase kinase 1 upregulation during the first hours of hypoxic treatment in hepatocellular carcinoma cells

The pyruvate dehydrogenase complex (PDC) is an important gatekeeper enzyme connecting glycolysis to the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS). Thereby, it has a strong impact on the glycolytic flux as well as the metabolic phenotype of a cell. PDC activity is regulate...

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Detalles Bibliográficos
Autores principales:	Zimmer, Andreas David, Walbrecq, Geoffroy, Kozar, Ines, Behrmann, Iris, Haan, Claude
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2016
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085306/ https://www.ncbi.nlm.nih.gov/pubmed/27800515 http://dx.doi.org/10.2147/HP.S99044

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