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Radiological Patterns of Brain Metastases in Breast Cancer Patients: A Subproject of the German Brain Metastases in Breast Cancer (BMBC) Registry

Evidence about distribution patterns of brain metastases with regard to breast cancer subtypes and its influence on the prognosis of patients is insufficient. Clinical data, cranial computed tomography (CT) and magnetic resonance imaging (MRI) scans of 300 breast cancer patients with brain metastase...

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Autores principales: Laakmann, Elena, Witzel, Isabell, Scriba, Verena, Grzyska, Ulrich, zu Eulenburg, Christine, Burchardi, Nicole, Hesse, Tobias, Würschmidt, Florian, Fehm, Tanja, Möbus, Volker, von Minckwitz, Gunter, Loibl, Sibylle, Park-Simon, Tjoung-Won, Mueller, Volkmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085648/
https://www.ncbi.nlm.nih.gov/pubmed/27669228
http://dx.doi.org/10.3390/ijms17101615
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author Laakmann, Elena
Witzel, Isabell
Scriba, Verena
Grzyska, Ulrich
zu Eulenburg, Christine
Burchardi, Nicole
Hesse, Tobias
Würschmidt, Florian
Fehm, Tanja
Möbus, Volker
von Minckwitz, Gunter
Loibl, Sibylle
Park-Simon, Tjoung-Won
Mueller, Volkmar
author_facet Laakmann, Elena
Witzel, Isabell
Scriba, Verena
Grzyska, Ulrich
zu Eulenburg, Christine
Burchardi, Nicole
Hesse, Tobias
Würschmidt, Florian
Fehm, Tanja
Möbus, Volker
von Minckwitz, Gunter
Loibl, Sibylle
Park-Simon, Tjoung-Won
Mueller, Volkmar
author_sort Laakmann, Elena
collection PubMed
description Evidence about distribution patterns of brain metastases with regard to breast cancer subtypes and its influence on the prognosis of patients is insufficient. Clinical data, cranial computed tomography (CT) and magnetic resonance imaging (MRI) scans of 300 breast cancer patients with brain metastases (BMs) were collected retrospectively in four centers participating in the Brain Metastases in Breast Cancer Registry (BMBC) in Germany. Patients with positive estrogen (ER), progesterone (PR), or human epidermal growth factor receptor 2 (HER2) statuses, had a significantly lower number of BMs at diagnosis. Concerning the treatment mode, HER2-positive patients treated with trastuzumab before the diagnosis of BMs showed a lower number of intracranial metastases (p < 0.001). Patients with a HER2-positive tumor-subtype developed cerebellar metastases more often compared with HER2-negative patients (59.8% vs. 44.5%, p = 0.021), whereas patients with triple-negative primary tumors had leptomeningeal disease more often (31.4% vs. 18.3%, p = 0.038). The localization of Brain metastases (BMs) was associated with prognosis: patients with leptomeningeal disease had shorter survival compared with patients without signs of leptomeningeal disease (median survival 3 vs. 5 months, p = 0.025). A shorter survival could also be observed in the patients with metastases in the occipital lobe (median survival 3 vs. 5 months, p = 0.012). Our findings suggest a different tumor cell homing to different brain regions depending on subtype and treatment.
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spelling pubmed-50856482016-11-01 Radiological Patterns of Brain Metastases in Breast Cancer Patients: A Subproject of the German Brain Metastases in Breast Cancer (BMBC) Registry Laakmann, Elena Witzel, Isabell Scriba, Verena Grzyska, Ulrich zu Eulenburg, Christine Burchardi, Nicole Hesse, Tobias Würschmidt, Florian Fehm, Tanja Möbus, Volker von Minckwitz, Gunter Loibl, Sibylle Park-Simon, Tjoung-Won Mueller, Volkmar Int J Mol Sci Article Evidence about distribution patterns of brain metastases with regard to breast cancer subtypes and its influence on the prognosis of patients is insufficient. Clinical data, cranial computed tomography (CT) and magnetic resonance imaging (MRI) scans of 300 breast cancer patients with brain metastases (BMs) were collected retrospectively in four centers participating in the Brain Metastases in Breast Cancer Registry (BMBC) in Germany. Patients with positive estrogen (ER), progesterone (PR), or human epidermal growth factor receptor 2 (HER2) statuses, had a significantly lower number of BMs at diagnosis. Concerning the treatment mode, HER2-positive patients treated with trastuzumab before the diagnosis of BMs showed a lower number of intracranial metastases (p < 0.001). Patients with a HER2-positive tumor-subtype developed cerebellar metastases more often compared with HER2-negative patients (59.8% vs. 44.5%, p = 0.021), whereas patients with triple-negative primary tumors had leptomeningeal disease more often (31.4% vs. 18.3%, p = 0.038). The localization of Brain metastases (BMs) was associated with prognosis: patients with leptomeningeal disease had shorter survival compared with patients without signs of leptomeningeal disease (median survival 3 vs. 5 months, p = 0.025). A shorter survival could also be observed in the patients with metastases in the occipital lobe (median survival 3 vs. 5 months, p = 0.012). Our findings suggest a different tumor cell homing to different brain regions depending on subtype and treatment. MDPI 2016-09-23 /pmc/articles/PMC5085648/ /pubmed/27669228 http://dx.doi.org/10.3390/ijms17101615 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Laakmann, Elena
Witzel, Isabell
Scriba, Verena
Grzyska, Ulrich
zu Eulenburg, Christine
Burchardi, Nicole
Hesse, Tobias
Würschmidt, Florian
Fehm, Tanja
Möbus, Volker
von Minckwitz, Gunter
Loibl, Sibylle
Park-Simon, Tjoung-Won
Mueller, Volkmar
Radiological Patterns of Brain Metastases in Breast Cancer Patients: A Subproject of the German Brain Metastases in Breast Cancer (BMBC) Registry
title Radiological Patterns of Brain Metastases in Breast Cancer Patients: A Subproject of the German Brain Metastases in Breast Cancer (BMBC) Registry
title_full Radiological Patterns of Brain Metastases in Breast Cancer Patients: A Subproject of the German Brain Metastases in Breast Cancer (BMBC) Registry
title_fullStr Radiological Patterns of Brain Metastases in Breast Cancer Patients: A Subproject of the German Brain Metastases in Breast Cancer (BMBC) Registry
title_full_unstemmed Radiological Patterns of Brain Metastases in Breast Cancer Patients: A Subproject of the German Brain Metastases in Breast Cancer (BMBC) Registry
title_short Radiological Patterns of Brain Metastases in Breast Cancer Patients: A Subproject of the German Brain Metastases in Breast Cancer (BMBC) Registry
title_sort radiological patterns of brain metastases in breast cancer patients: a subproject of the german brain metastases in breast cancer (bmbc) registry
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085648/
https://www.ncbi.nlm.nih.gov/pubmed/27669228
http://dx.doi.org/10.3390/ijms17101615
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