Cinnamide Derivatives as Mammalian Arginase Inhibitors: Synthesis, Biological Evaluation and Molecular Docking

Arginases are enzymes that are involved in many human diseases and have been targeted for new treatments. Here a series of cinnamides was designed, synthesized and evaluated in vitro and in silico for their inhibitory activity against mammalian arginase. Using a microassay on purified liver bovine a...

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Detalles Bibliográficos
Autores principales: Pham, Thanh-Nhat, Bordage, Simon, Pudlo, Marc, Demougeot, Céline, Thai, Khac-Minh, Girard-Thernier, Corine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085689/
https://www.ncbi.nlm.nih.gov/pubmed/27690022
http://dx.doi.org/10.3390/ijms17101656

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085689/
https://www.ncbi.nlm.nih.gov/pubmed/27690022
http://dx.doi.org/10.3390/ijms17101656

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