Racemization of the Succinimide Intermediate Formed in Proteins and Peptides: A Computational Study of the Mechanism Catalyzed by Dihydrogen Phosphate Ion

In proteins and peptides, d-aspartic acid (d-Asp) and d-β-Asp residues can be spontaneously formed via racemization of the succinimide intermediate formed from l-Asp and l-asparagine (l-Asn) residues. These biologically uncommon amino acid residues are known to have relevance to aging and pathologie...

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Detalles Bibliográficos
Autores principales: Takahashi, Ohgi, Kirikoshi, Ryota, Manabe, Noriyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085730/
https://www.ncbi.nlm.nih.gov/pubmed/27735868
http://dx.doi.org/10.3390/ijms17101698

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085730/
https://www.ncbi.nlm.nih.gov/pubmed/27735868
http://dx.doi.org/10.3390/ijms17101698

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