Cargando…

Role of Intracellular Lipid Logistics in the Preferential Usage of Very Long Chain-Ceramides in Glucosylceramide

Ceramide is a common precursor of sphingomyelin (SM) and glycosphingolipids (GSLs) in mammalian cells. Ceramide synthase 2 (CERS2), one of the six ceramide synthase isoforms, is responsible for the synthesis of very long chain fatty acid (C20–26 fatty acids) (VLC)-containing ceramides (VLC-Cer). It...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yamaji, Toshiyuki, Horie, Aya, Tachida, Yuriko, Sakuma, Chisato, Suzuki, Yusuke, Kushi, Yasunori, Hanada, Kentaro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085785/ https://www.ncbi.nlm.nih.gov/pubmed/27775668 http://dx.doi.org/10.3390/ijms17101761

Ejemplares similares

A CRISPR Screen Identifies LAPTM4A and TM9SF Proteins as Glycolipid-Regulating Factors
por: Yamaji, Toshiyuki, et al.
Publicado: (2019)

Compartmentalization of casein kinase 1 γ CSNK1G controls the intracellular trafficking of ceramide
por: Goto, Asako, et al.
Publicado: (2022)

Ceramides and glucosylceramides are independent antagonists of insulin action
por: Chavez, Jose A, et al.
Publicado: (2012)

The C10orf76–PI4KB axis orchestrates CERT-mediated ceramide trafficking to the distal Golgi
por: Mizuike, Aya, et al.
Publicado: (2023)

Intracellular trafficking of ceramide by ceramide transfer protein
por: Hanada, Kentaro
Publicado: (2010)

Identification of SYS1 as a Host Factor Required for Shiga Toxin-Mediated Cytotoxicity in Vero Cells
por: Sakuma, Chisato, et al.
Publicado: (2021)

Preferential killing of multidrug-resistant KB cells by inhibitors of glucosylceramide synthase
por: Nicholson, K M, et al.
Publicado: (1999)

Control of Glucosylceramide Production and Morphogenesis by the Bar1 Ceramide Synthase in Fusarium graminearum
por: Rittenour, William R., et al.
Publicado: (2011)

Selective Targeting of the Interconversion between Glucosylceramide and Ceramide by Scaffold Tailoring of Iminosugar Inhibitors
por: Baudoin-Dehoux, Cécile, et al.
Publicado: (2019)

Involvement of a Cluster of Basic Amino Acids in Phosphorylation-Dependent Functional Repression of the Ceramide Transport Protein CERT
por: Goto, Asako, et al.
Publicado: (2022)

Horse-Derived Ceramide Accentuates Glucosylceramide Synthase and Ceramide Synthase 3 by Activating PPARβ/δ and/or PPARγ to Stimulate Ceramide Synthesis
por: Igarashi, Tami, et al.
Publicado: (2023)

Comparative Study on Epidermal Moisturizing Effects and Hydration Mechanisms of Rice-Derived Glucosylceramides and Ceramides
por: Takeda, Shogo, et al.
Publicado: (2022)

Incorporation of Fluorescence Ceramide-Based HPLC Assay for Rapidly and Efficiently Assessing Glucosylceramide Synthase In Vivo
por: Khiste, Sachin K., et al.
Publicado: (2017)

Whole-Genome Sequencing of Vero E6 (VERO C1008) and Comparative Analysis of Four Vero Cell Sublines
por: Konishi, Kazuhiro, et al.
Publicado: (2022)

Plasma Ceramide and Glucosylceramide Metabolism Is Altered in Sporadic Parkinson's Disease and Associated with Cognitive Impairment: A Pilot Study
por: Mielke, Michelle M., et al.
Publicado: (2013)

Novel endogenous simian retroviral integrations in Vero cells: implications for quality control of a human vaccine cell substrate
por: Sakuma, Chisato, et al.
Publicado: (2018)

Oral Administration of Glucosylceramide Suppresses Tumor Growth by Affecting the Ceramide/Sphingosine-1-Phosphate Balance in Breast Cancer Tissue
por: Moro, Kazuki, et al.
Publicado: (2023)

Establishment of HeLa Cell Mutants Deficient in Sphingolipid-Related Genes Using TALENs
por: Yamaji, Toshiyuki, et al.
Publicado: (2014)

Glucosylceramide Synthase Inhibitors Induce Ceramide Accumulation and Sensitize H3K27 Mutant Diffuse Midline Glioma to Irradiation
por: El Malki, Khalifa, et al.
Publicado: (2023)

Natural Ligand-Mimetic and Nonmimetic Inhibitors of the Ceramide Transport Protein CERT
por: Hanada, Kentaro, et al.
Publicado: (2022)

Development of a Label-Free LC-MS/MS-Based Glucosylceramide Synthase Assay and Its Application to Inhibitors Screening for Ceramide-Related Diseases
por: Fu, Zhicheng, et al.
Publicado: (2019)

β-Sitosterol 3-O-D-glucoside increases ceramide levels in the stratum corneum via the up-regulated expression of ceramide synthase-3 and glucosylceramide synthase in a reconstructed human epidermal keratinization model
por: Takeda, Shogo, et al.
Publicado: (2021)

Synthesis and Biological Properties of Fungal Glucosylceramide
por: Del Poeta, Maurizio, et al.
Publicado: (2014)

Defining the glucosylceramide population of C. elegans
por: Xatse, Mark A., et al.
Publicado: (2023)

Correction: Synthesis and Biological Properties of Fungal Glucosylceramide
por: Del Poeta, Maurizio, et al.
Publicado: (2015)

Hyperosmotic Stress Induces Phosphorylation of CERT and Enhances Its Tethering throughout the Endoplasmic Reticulum
por: Shimasaki, Kentaro, et al.
Publicado: (2022)

Ubiquitous Transgene Expression of the Glucosylceramide-Synthesizing Enzyme Accelerates Glucosylceramide Accumulation and Storage Cells in a Gaucher Disease Mouse Model
por: Barnes, Sonya, et al.
Publicado: (2014)

Intellectual-disability-associated mutations in the ceramide transport protein gene CERT1 lead to aberrant function and subcellular distribution
por: Tamura, Norito, et al.
Publicado: (2021)

Intellectual disability-associated gain-of-function mutations in CERT1 that encodes the ceramide transport protein CERT
por: Murakami, Hiroaki, et al.
Publicado: (2020)

Genetic Evidence for ATP-dependent Endoplasmic Reticulum-to-Golgi Apparatus Trafficking of Ceramide for Sphingomyelin Synthesis in Chinese Hamster Ovary Cells
por: Fukasawa, Masayoshi, et al.
Publicado: (1999)

Glucosylceramide is synthesized at the cytosolic surface of various Golgi subfractions
Publicado: (1992)

Pre- and post-Golgi translocation of glucosylceramide in glycosphingolipid synthesis
por: Halter, David, et al.
Publicado: (2007)

Administration of Glucosylceramide Ameliorated the Memory Impairment in Aged Mice
por: Lee, Yeonju, et al.
Publicado: (2013)

Glucosylceramide synthase maintains influenza virus entry and infection
por: Drews, Kelly, et al.
Publicado: (2020)

Chlamydial Infection-Dependent Synthesis of Sphingomyelin as a Novel Anti-Chlamydial Target of Ceramide Mimetic Compounds
por: Kumagai, Keigo, et al.
Publicado: (2022)

ARF6 Regulates Neuron Differentiation through Glucosylceramide Synthase
por: Li, Lu, et al.
Publicado: (2013)

Glucosylceramide Administration as a Vaccination Strategy in Mouse Models of Cryptococcosis
por: Mor, Visesato, et al.
Publicado: (2016)

New Insights on Glucosylceramide Synthase in Cancer Drug Resistance and Myelosuppression
por: Gupta, Vineet, et al.
Publicado: (2013)

Transmembrane transporter expression regulated by the glucosylceramide pathway in Cryptococcus neoformans
por: Singh, Arpita, et al.
Publicado: (2015)

Effects of Peach (Prunus persica)-Derived Glucosylceramide on the Human Skin
por: Koikeda, Takashi, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_0i4ktgnh02avi7knkfe99ouhbb