Genetic Characteristics and Immunogenicity of Pandemic H1N1 Influenza Virus Isolate from Pig in Korea

A pandemic influenza A (H1N1) virus strain was isolated from a pig farm in Korea in December 2009. The strain was propagated in and isolated from both the Madin-Darby canine kidney cell line and embryonated eggs. The partial and complete sequences of the strain were identical to those of A/Californi...

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Detalles Bibliográficos
Autores principales: Moon, Hyoung Joon, Oh, Jin Sik, Na, Woonsung, Yeom, Minjoo, Han, Sang Yoon, Kim, Sung Jae, Park, Bong Kyun, Song, Dae Sub, Kang, Bo Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Immunologists 2016
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086456/
https://www.ncbi.nlm.nih.gov/pubmed/27799877
http://dx.doi.org/10.4110/in.2016.16.5.311
Descripción
Sumario:A pandemic influenza A (H1N1) virus strain was isolated from a pig farm in Korea in December 2009. The strain was propagated in and isolated from both the Madin-Darby canine kidney cell line and embryonated eggs. The partial and complete sequences of the strain were identical to those of A/California/04/2009, with >99% sequence similarity in the HA, NA, M, NS, NP, PA, PB1, and PB2 genes. The isolated strain was inactivated and used to prepare a swine influenza vaccine. This trial vaccine, containing the new isolate that has high sequence similarity with the pandemic influenza A (H1N1) virus, resulted in seroconversion in Guinea pigs and piglets. This strain could therefore be a potential vaccine candidate for swine influenza control in commercial farms.

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