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Salvage brachytherapy for local recurrences of prostate cancer treated previously with radiotherapy
PURPOSE: The aim of the study was to analyze early effects and toxicity of salvage high dose rate brachytherapy for local recurrences of adenocarcinoma of the prostate after external beam radiotherapy (EBRT). MATERIAL AND METHODS: In MCS Memorial Institute of Oncology in Gliwice a research programme...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086488/ https://www.ncbi.nlm.nih.gov/pubmed/28050174 |
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author | Gawkowska-Suwinska, Marzena Fijałkowski, Marek Białas, Brygida Szlag, Marta Kellas-Ślęczka, Sylwia Nowicka, Elżbieta Behrendt, Katarzyna Plewicki, Grzegorz Smolska-Ciszewska, Beata Giglok, Monika Zajusz, Aleksander Owczarek, Grzegorz |
author_facet | Gawkowska-Suwinska, Marzena Fijałkowski, Marek Białas, Brygida Szlag, Marta Kellas-Ślęczka, Sylwia Nowicka, Elżbieta Behrendt, Katarzyna Plewicki, Grzegorz Smolska-Ciszewska, Beata Giglok, Monika Zajusz, Aleksander Owczarek, Grzegorz |
author_sort | Gawkowska-Suwinska, Marzena |
collection | PubMed |
description | PURPOSE: The aim of the study was to analyze early effects and toxicity of salvage high dose rate brachytherapy for local recurrences of adenocarcinoma of the prostate after external beam radiotherapy (EBRT). MATERIAL AND METHODS: In MCS Memorial Institute of Oncology in Gliwice a research programme on salvage HDR brachytherapy for local recurrences of prostate cancer treated previously with EBRT has been ongoing since February 2008. The treatment consisted of 3 fractions of 10 Gy each given every 14 days. Maximal urethral doses were constrained to be ≤ 120% of the prescribed dose. Maximal bladder and rectum doses were constrained to be ≤ 70% of the prescribed dose. RESULTS: Fifteen eligible patients were treated and analyzed from February 2008. All patients completed the treatment without major complications. The most common early complications were: macroscopic haematuria, pain in lower part of the abdomen, and transient dysuria. During the first week after the procedure a transient increase in IPSS score was noticed. The Foley catheter was removed on day 2 to 5. No complications after spinal anaesthesia were observed. Acute toxicity according to EORTC/RTOG was low. For bladder EORTC/RTOG score ranged from 0 to 2. Only in two patients grade 1 toxicity for rectum was observed. The follow-up ranged from 3 to 9 months. In one patient grade 2 rectal toxicity was observed, and one had urethral stricture. Other patients did not have any other significant late toxicity of the treatment. Two patients developed bone metastases. CONCLUSIONS: Salvage brachytherapy for localized prostate cancer (3 × 10 Gy every 14 days) seems to be a safe and well tolerated procedure. A significant decline in prostate-specific antigen (PSA) level is seen in patients with hormone-responsive cancer. Long-term efficiency and toxicity of the procedure are yet to be established. |
format | Online Article Text |
id | pubmed-5086488 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-50864882017-01-03 Salvage brachytherapy for local recurrences of prostate cancer treated previously with radiotherapy Gawkowska-Suwinska, Marzena Fijałkowski, Marek Białas, Brygida Szlag, Marta Kellas-Ślęczka, Sylwia Nowicka, Elżbieta Behrendt, Katarzyna Plewicki, Grzegorz Smolska-Ciszewska, Beata Giglok, Monika Zajusz, Aleksander Owczarek, Grzegorz J Contemp Brachytherapy Original Article PURPOSE: The aim of the study was to analyze early effects and toxicity of salvage high dose rate brachytherapy for local recurrences of adenocarcinoma of the prostate after external beam radiotherapy (EBRT). MATERIAL AND METHODS: In MCS Memorial Institute of Oncology in Gliwice a research programme on salvage HDR brachytherapy for local recurrences of prostate cancer treated previously with EBRT has been ongoing since February 2008. The treatment consisted of 3 fractions of 10 Gy each given every 14 days. Maximal urethral doses were constrained to be ≤ 120% of the prescribed dose. Maximal bladder and rectum doses were constrained to be ≤ 70% of the prescribed dose. RESULTS: Fifteen eligible patients were treated and analyzed from February 2008. All patients completed the treatment without major complications. The most common early complications were: macroscopic haematuria, pain in lower part of the abdomen, and transient dysuria. During the first week after the procedure a transient increase in IPSS score was noticed. The Foley catheter was removed on day 2 to 5. No complications after spinal anaesthesia were observed. Acute toxicity according to EORTC/RTOG was low. For bladder EORTC/RTOG score ranged from 0 to 2. Only in two patients grade 1 toxicity for rectum was observed. The follow-up ranged from 3 to 9 months. In one patient grade 2 rectal toxicity was observed, and one had urethral stricture. Other patients did not have any other significant late toxicity of the treatment. Two patients developed bone metastases. CONCLUSIONS: Salvage brachytherapy for localized prostate cancer (3 × 10 Gy every 14 days) seems to be a safe and well tolerated procedure. A significant decline in prostate-specific antigen (PSA) level is seen in patients with hormone-responsive cancer. Long-term efficiency and toxicity of the procedure are yet to be established. Termedia Publishing House 2010-01-13 2009-12 /pmc/articles/PMC5086488/ /pubmed/28050174 Text en Copyright: © 2010 Termedia Sp. z o. o. http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license. |
spellingShingle | Original Article Gawkowska-Suwinska, Marzena Fijałkowski, Marek Białas, Brygida Szlag, Marta Kellas-Ślęczka, Sylwia Nowicka, Elżbieta Behrendt, Katarzyna Plewicki, Grzegorz Smolska-Ciszewska, Beata Giglok, Monika Zajusz, Aleksander Owczarek, Grzegorz Salvage brachytherapy for local recurrences of prostate cancer treated previously with radiotherapy |
title | Salvage brachytherapy for local recurrences of prostate cancer treated previously with radiotherapy |
title_full | Salvage brachytherapy for local recurrences of prostate cancer treated previously with radiotherapy |
title_fullStr | Salvage brachytherapy for local recurrences of prostate cancer treated previously with radiotherapy |
title_full_unstemmed | Salvage brachytherapy for local recurrences of prostate cancer treated previously with radiotherapy |
title_short | Salvage brachytherapy for local recurrences of prostate cancer treated previously with radiotherapy |
title_sort | salvage brachytherapy for local recurrences of prostate cancer treated previously with radiotherapy |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086488/ https://www.ncbi.nlm.nih.gov/pubmed/28050174 |
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