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Effect of Topical Administration of Fractions and Isolated Molecules from Plant Extracts on Skin Wound Healing: A Systematic Review of Murine Experimental Models

Background and Purpose. Skin wound healing is a dynamic process driven by molecular events responsible for the morphofunctional repair of the injured tissue. In a systematic review, we analyzed the relevance of plant fractions and isolates on skin wound healing. By revising preclinical investigation...

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Autores principales: Sarandy, Mariáurea Matias, Lopes, Fernanda Barbosa, da Matta, Sérgio Luis Pinto, Pinto, Marcus Vinicius Mello, Sartori, Sirlene Souza Rodrigues, Novaes, Rômulo Dias, Golçalves, Reggiani Vilela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086515/
https://www.ncbi.nlm.nih.gov/pubmed/27829707
http://dx.doi.org/10.1155/2016/4916068
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author Sarandy, Mariáurea Matias
Lopes, Fernanda Barbosa
da Matta, Sérgio Luis Pinto
Pinto, Marcus Vinicius Mello
Sartori, Sirlene Souza Rodrigues
Novaes, Rômulo Dias
Golçalves, Reggiani Vilela
author_facet Sarandy, Mariáurea Matias
Lopes, Fernanda Barbosa
da Matta, Sérgio Luis Pinto
Pinto, Marcus Vinicius Mello
Sartori, Sirlene Souza Rodrigues
Novaes, Rômulo Dias
Golçalves, Reggiani Vilela
author_sort Sarandy, Mariáurea Matias
collection PubMed
description Background and Purpose. Skin wound healing is a dynamic process driven by molecular events responsible for the morphofunctional repair of the injured tissue. In a systematic review, we analyzed the relevance of plant fractions and isolates on skin wound healing. By revising preclinical investigations with murine models, we investigated if the current evidence could support clinical trials. Methods. Studies were selected in the MEDLINE/PubMed and Scopus databases according to the PRISMA statement. All 32 identified studies were submitted to data extraction and the methodological bias was investigated according to ARRIVE strategy. Results. The studies demonstrated that plant fractions and isolates are able to modulate the inflammatory process during skin wound healing, being also effective in attenuating the oxidative tissue damage in the scar tissue and stimulating cell proliferation, neoangiogenesis, collagen synthesis, granulation tissue expansion, reepithelialization, and the wound closure rate. However, we identified serious methodological flaws in all studies, such as the high level of reporting bias and absence of standardized experimental designs, analytical methods, and outcome measures. Conclusion. Considering these limitations, the current evidence generated from flawed methodological animal studies makes it difficult to determine the relevance of herbal medicines to treat skin wounds and derails conducting clinical studies.
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spelling pubmed-50865152016-11-09 Effect of Topical Administration of Fractions and Isolated Molecules from Plant Extracts on Skin Wound Healing: A Systematic Review of Murine Experimental Models Sarandy, Mariáurea Matias Lopes, Fernanda Barbosa da Matta, Sérgio Luis Pinto Pinto, Marcus Vinicius Mello Sartori, Sirlene Souza Rodrigues Novaes, Rômulo Dias Golçalves, Reggiani Vilela Mediators Inflamm Review Article Background and Purpose. Skin wound healing is a dynamic process driven by molecular events responsible for the morphofunctional repair of the injured tissue. In a systematic review, we analyzed the relevance of plant fractions and isolates on skin wound healing. By revising preclinical investigations with murine models, we investigated if the current evidence could support clinical trials. Methods. Studies were selected in the MEDLINE/PubMed and Scopus databases according to the PRISMA statement. All 32 identified studies were submitted to data extraction and the methodological bias was investigated according to ARRIVE strategy. Results. The studies demonstrated that plant fractions and isolates are able to modulate the inflammatory process during skin wound healing, being also effective in attenuating the oxidative tissue damage in the scar tissue and stimulating cell proliferation, neoangiogenesis, collagen synthesis, granulation tissue expansion, reepithelialization, and the wound closure rate. However, we identified serious methodological flaws in all studies, such as the high level of reporting bias and absence of standardized experimental designs, analytical methods, and outcome measures. Conclusion. Considering these limitations, the current evidence generated from flawed methodological animal studies makes it difficult to determine the relevance of herbal medicines to treat skin wounds and derails conducting clinical studies. Hindawi Publishing Corporation 2016 2016-10-17 /pmc/articles/PMC5086515/ /pubmed/27829707 http://dx.doi.org/10.1155/2016/4916068 Text en Copyright © 2016 Mariáurea Matias Sarandy et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Sarandy, Mariáurea Matias
Lopes, Fernanda Barbosa
da Matta, Sérgio Luis Pinto
Pinto, Marcus Vinicius Mello
Sartori, Sirlene Souza Rodrigues
Novaes, Rômulo Dias
Golçalves, Reggiani Vilela
Effect of Topical Administration of Fractions and Isolated Molecules from Plant Extracts on Skin Wound Healing: A Systematic Review of Murine Experimental Models
title Effect of Topical Administration of Fractions and Isolated Molecules from Plant Extracts on Skin Wound Healing: A Systematic Review of Murine Experimental Models
title_full Effect of Topical Administration of Fractions and Isolated Molecules from Plant Extracts on Skin Wound Healing: A Systematic Review of Murine Experimental Models
title_fullStr Effect of Topical Administration of Fractions and Isolated Molecules from Plant Extracts on Skin Wound Healing: A Systematic Review of Murine Experimental Models
title_full_unstemmed Effect of Topical Administration of Fractions and Isolated Molecules from Plant Extracts on Skin Wound Healing: A Systematic Review of Murine Experimental Models
title_short Effect of Topical Administration of Fractions and Isolated Molecules from Plant Extracts on Skin Wound Healing: A Systematic Review of Murine Experimental Models
title_sort effect of topical administration of fractions and isolated molecules from plant extracts on skin wound healing: a systematic review of murine experimental models
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086515/
https://www.ncbi.nlm.nih.gov/pubmed/27829707
http://dx.doi.org/10.1155/2016/4916068
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