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The Bone Sparing Effects of 2-Methoxyestradiol Are Mediated via Estrogen Receptor-α in Male Mice

2-Methoxyestradiol (2ME2), a metabolite of 17β-estradiol (E2), exerts bone sparing effects in animal models. We hypothesized that the underlying mechanism is back conversion of 2ME2 to E2, which subsequently acts via estrogen receptor (ER)α. We measured serum E2 levels in orchidectomized wild-type (...

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Detalles Bibliográficos
Autores principales:	Eriksson, Anna L., Wilhelmson, Anna S., Fagman, Johan B., Ryberg, Henrik, Koskela, Antti, Tuukkanen, Juha, Tivesten, Åsa, Ohlsson, Claes
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Endocrine Society 2016
Materias:	Brief Research Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086527/ https://www.ncbi.nlm.nih.gov/pubmed/27631553 http://dx.doi.org/10.1210/en.2016-1402

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