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Strengthened Corticosubcortical Functional Connectivity during Muscle Fatigue

The present study examined functional connectivity (FC) between functional MRI (fMRI) signals of the primary motor cortex (M1) and each of the three subcortical neural structures, cerebellum (CB), basal ganglia (BG), and thalamus (TL), during muscle fatigue using the quantile regression technique. U...

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Autores principales: Jiang, Zhiguo, Wang, Xiao-Feng, Yue, Guang H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086541/
https://www.ncbi.nlm.nih.gov/pubmed/27830093
http://dx.doi.org/10.1155/2016/1726848
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author Jiang, Zhiguo
Wang, Xiao-Feng
Yue, Guang H.
author_facet Jiang, Zhiguo
Wang, Xiao-Feng
Yue, Guang H.
author_sort Jiang, Zhiguo
collection PubMed
description The present study examined functional connectivity (FC) between functional MRI (fMRI) signals of the primary motor cortex (M1) and each of the three subcortical neural structures, cerebellum (CB), basal ganglia (BG), and thalamus (TL), during muscle fatigue using the quantile regression technique. Understanding activation relation between the subcortical structures and the M1 during prolonged motor performance should help delineate how central motor control network modulates acute perturbations at peripheral sensorimotor system such as muscle fatigue. Ten healthy subjects participated in the study and completed a 20-minute intermittent handgrip motor task at 50% of their maximal voluntary contraction (MVC) level. Quantile regression analyses were carried out to compare the FC between the contralateral (left) M1 and CB, BG, and TL in the minimal (beginning 100 s) versus significant (ending 100 s) fatigue stages. Widespread, statistically significant increases in FC were found in bilateral BG, CB, and TL with the left M1 during significant versus minimal fatigue stages. Our results imply that these subcortical nuclei are critical components in the motor control network and actively involved in modulating voluntary muscle fatigue, possibly, by working together with the M1 to strengthen the descending central command to prolong the motor performance.
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spelling pubmed-50865412016-11-09 Strengthened Corticosubcortical Functional Connectivity during Muscle Fatigue Jiang, Zhiguo Wang, Xiao-Feng Yue, Guang H. Neural Plast Research Article The present study examined functional connectivity (FC) between functional MRI (fMRI) signals of the primary motor cortex (M1) and each of the three subcortical neural structures, cerebellum (CB), basal ganglia (BG), and thalamus (TL), during muscle fatigue using the quantile regression technique. Understanding activation relation between the subcortical structures and the M1 during prolonged motor performance should help delineate how central motor control network modulates acute perturbations at peripheral sensorimotor system such as muscle fatigue. Ten healthy subjects participated in the study and completed a 20-minute intermittent handgrip motor task at 50% of their maximal voluntary contraction (MVC) level. Quantile regression analyses were carried out to compare the FC between the contralateral (left) M1 and CB, BG, and TL in the minimal (beginning 100 s) versus significant (ending 100 s) fatigue stages. Widespread, statistically significant increases in FC were found in bilateral BG, CB, and TL with the left M1 during significant versus minimal fatigue stages. Our results imply that these subcortical nuclei are critical components in the motor control network and actively involved in modulating voluntary muscle fatigue, possibly, by working together with the M1 to strengthen the descending central command to prolong the motor performance. Hindawi Publishing Corporation 2016 2016-10-17 /pmc/articles/PMC5086541/ /pubmed/27830093 http://dx.doi.org/10.1155/2016/1726848 Text en Copyright © 2016 Zhiguo Jiang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Jiang, Zhiguo
Wang, Xiao-Feng
Yue, Guang H.
Strengthened Corticosubcortical Functional Connectivity during Muscle Fatigue
title Strengthened Corticosubcortical Functional Connectivity during Muscle Fatigue
title_full Strengthened Corticosubcortical Functional Connectivity during Muscle Fatigue
title_fullStr Strengthened Corticosubcortical Functional Connectivity during Muscle Fatigue
title_full_unstemmed Strengthened Corticosubcortical Functional Connectivity during Muscle Fatigue
title_short Strengthened Corticosubcortical Functional Connectivity during Muscle Fatigue
title_sort strengthened corticosubcortical functional connectivity during muscle fatigue
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086541/
https://www.ncbi.nlm.nih.gov/pubmed/27830093
http://dx.doi.org/10.1155/2016/1726848
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