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Reconstruction for Limited-Projection Fluorescence Molecular Tomography Based on a Double-Mesh Strategy

Limited-projection fluorescence molecular tomography (FMT) has short data acquisition time that allows fast resolving of the three-dimensional visualization of fluorophore within small animal in vivo. However, limited-projection FMT reconstruction suffers from severe ill-posedness because only limit...

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Detalles Bibliográficos
Autores principales: Yi, Huangjian, Zhang, Xu, Peng, Jinye, Zhao, Fengjun, Wang, Xiaodong, Hou, Yuqing, Chen, Duofang, He, Xiaowei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086542/
https://www.ncbi.nlm.nih.gov/pubmed/27830148
http://dx.doi.org/10.1155/2016/5682851
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author Yi, Huangjian
Zhang, Xu
Peng, Jinye
Zhao, Fengjun
Wang, Xiaodong
Hou, Yuqing
Chen, Duofang
He, Xiaowei
author_facet Yi, Huangjian
Zhang, Xu
Peng, Jinye
Zhao, Fengjun
Wang, Xiaodong
Hou, Yuqing
Chen, Duofang
He, Xiaowei
author_sort Yi, Huangjian
collection PubMed
description Limited-projection fluorescence molecular tomography (FMT) has short data acquisition time that allows fast resolving of the three-dimensional visualization of fluorophore within small animal in vivo. However, limited-projection FMT reconstruction suffers from severe ill-posedness because only limited projections are used for reconstruction. To alleviate the ill-posedness, a feasible region extraction strategy based on a double mesh is presented for limited-projection FMT. First, an initial result is rapidly recovered using a coarse discretization mesh. Then, the reconstructed fluorophore area in the initial result is selected as a feasible region to guide the reconstruction using a fine discretization mesh. Simulation experiments on a digital mouse and small animal experiment in vivo are performed to validate the proposed strategy. It demonstrates that the presented strategy provides a good distribution of fluorophore with limited projections of fluorescence measurements. Hence, it is suitable for reconstruction of limited-projection FMT.
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spelling pubmed-50865422016-11-09 Reconstruction for Limited-Projection Fluorescence Molecular Tomography Based on a Double-Mesh Strategy Yi, Huangjian Zhang, Xu Peng, Jinye Zhao, Fengjun Wang, Xiaodong Hou, Yuqing Chen, Duofang He, Xiaowei Biomed Res Int Research Article Limited-projection fluorescence molecular tomography (FMT) has short data acquisition time that allows fast resolving of the three-dimensional visualization of fluorophore within small animal in vivo. However, limited-projection FMT reconstruction suffers from severe ill-posedness because only limited projections are used for reconstruction. To alleviate the ill-posedness, a feasible region extraction strategy based on a double mesh is presented for limited-projection FMT. First, an initial result is rapidly recovered using a coarse discretization mesh. Then, the reconstructed fluorophore area in the initial result is selected as a feasible region to guide the reconstruction using a fine discretization mesh. Simulation experiments on a digital mouse and small animal experiment in vivo are performed to validate the proposed strategy. It demonstrates that the presented strategy provides a good distribution of fluorophore with limited projections of fluorescence measurements. Hence, it is suitable for reconstruction of limited-projection FMT. Hindawi Publishing Corporation 2016 2016-10-17 /pmc/articles/PMC5086542/ /pubmed/27830148 http://dx.doi.org/10.1155/2016/5682851 Text en Copyright © 2016 Huangjian Yi et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yi, Huangjian
Zhang, Xu
Peng, Jinye
Zhao, Fengjun
Wang, Xiaodong
Hou, Yuqing
Chen, Duofang
He, Xiaowei
Reconstruction for Limited-Projection Fluorescence Molecular Tomography Based on a Double-Mesh Strategy
title Reconstruction for Limited-Projection Fluorescence Molecular Tomography Based on a Double-Mesh Strategy
title_full Reconstruction for Limited-Projection Fluorescence Molecular Tomography Based on a Double-Mesh Strategy
title_fullStr Reconstruction for Limited-Projection Fluorescence Molecular Tomography Based on a Double-Mesh Strategy
title_full_unstemmed Reconstruction for Limited-Projection Fluorescence Molecular Tomography Based on a Double-Mesh Strategy
title_short Reconstruction for Limited-Projection Fluorescence Molecular Tomography Based on a Double-Mesh Strategy
title_sort reconstruction for limited-projection fluorescence molecular tomography based on a double-mesh strategy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086542/
https://www.ncbi.nlm.nih.gov/pubmed/27830148
http://dx.doi.org/10.1155/2016/5682851
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