Cargando…

Mutagenic Effects of Ribavirin on Hepatitis E Virus—Viral Extinction versus Selection of Fitness-Enhancing Mutations

Hepatitis E virus (HEV), an important agent of viral hepatitis worldwide, can cause severe courses of infection in pregnant women and immunosuppressed patients. To date, HEV infections can only be treated with ribavirin (RBV). Major drawbacks of this therapy are that RBV is not approved for administ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Todt, Daniel, Walter, Stephanie, Brown, Richard J. P., Steinmann, Eike
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086615/ https://www.ncbi.nlm.nih.gov/pubmed/27754363 http://dx.doi.org/10.3390/v8100283

Ejemplares similares

In vivo evidence for ribavirin-induced mutagenesis of the hepatitis E virus genome
por: Todt, Daniel, et al.
Publicado: (2016)

Counteracting Quasispecies Adaptability: Extinction of a Ribavirin-Resistant Virus Mutant by an Alternative Mutagenic Treatment
por: Perales, Celia, et al.
Publicado: (2009)

Hepatitis E Virus Drug Development
por: Kinast, Volker, et al.
Publicado: (2019)

Extinction of Hepatitis C Virus by Ribavirin in Hepatoma Cells Involves Lethal Mutagenesis
por: Ortega-Prieto, Ana M., et al.
Publicado: (2013)

Virus–Host Cell Interplay during Hepatitis E Virus Infection
por: Wißing, Michael H., et al.
Publicado: (2021)

A ribavirin-induced ORF2 single-nucleotide variant produces defective hepatitis E virus particles with immune decoy function
por: Meister, Toni Luise, et al.
Publicado: (2022)

Beyond the Usual Suspects: Hepatitis E Virus and Its Implications in Hepatocellular Carcinoma
por: Klöhn, Mara, et al.
Publicado: (2021)

Ledipasvir/sofosbuvir and ribavirin for the treatment of ribavirin-refractory persistent hepatitis E virus infection
por: Gallacher, Jennifer, et al.
Publicado: (2023)

Pegylated interferon may be considered in chronic viral hepatitis E resistant to ribavirin in kidney transplant recipients
por: Ollivier-Hourmand, I., et al.
Publicado: (2020)

Influence of Tattoo Ink on Hepatitis C Virus Infectiousness
por: Behrendt, Patrick, et al.
Publicado: (2019)

Viral Interference of Hepatitis C and E Virus Replication in Novel Experimental Co-Infection Systems
por: Burkard, Thomas, et al.
Publicado: (2022)

A Multi-Step Process of Viral Adaptation to a Mutagenic Nucleoside Analogue by Modulation of Transition Types Leads to Extinction-Escape
por: Agudo, Rubén, et al.
Publicado: (2010)

Selection of hepatitis C virus resistant to ribavirin
por: Feigelstock, Dino A, et al.
Publicado: (2011)

Ritonavir Blocks Hepatitis E Virus Internalization and Clears Hepatitis E Virus In Vitro with Ribavirin
por: Primadharsini, Putu Prathiwi, et al.
Publicado: (2022)

Chronic Hepatitis E Virus Infection during Lymphoplasmacytic Lymphoma and Ibrutinib Treatment
por: Schlevogt, Bernhard, et al.
Publicado: (2019)

Ribavirin for Chronic Hepatitis E Virus Infection in Ibrutinib-Exposed Patients
por: Protin, Caroline, et al.
Publicado: (2019)

Natural reservoirs for homologs of hepatitis C virus
por: Pfaender, Stephanie, et al.
Publicado: (2014)

High Environmental Stability of Hepatitis B Virus and Inactivation Requirements for Chemical Biocides
por: Than, Thoa Thi, et al.
Publicado: (2019)

Hepatitis C: viral and host factors associated with non-response to pegylated interferon plus ribavirin
por: Asselah, Tarik, et al.
Publicado: (2010)

Randomized Trial Evaluating the Impact of Ribavirin Mono-Therapy and Double Dosing on Viral Kinetics, Ribavirin Pharmacokinetics and Anemia in Hepatitis C Virus Genotype 1 Infection
por: Waldenström, Jesper, et al.
Publicado: (2016)

Does Mutational Robustness Inhibit Extinction by Lethal Mutagenesis in Viral Populations?
por: O'Dea, Eamon B., et al.
Publicado: (2010)

Ribavirin in Acute Hepatitis E Infection in Patients with Gynecological Cancer: A Case Series
por: Bettinger, Dominik, et al.
Publicado: (2018)

Plasma Hepatitis E Virus Kinetics in Solid Organ Transplant Patients Receiving Ribavirin
por: Lhomme, Sebastien, et al.
Publicado: (2019)

Determining the therapeutic range for ribavirin in transplant recipients with chronic hepatitis E virus infection
por: Mulder, Midas B., et al.
Publicado: (2020)

Hepatitis C Viral Kinetics as a Determinant of Stopping Pegylated Interferon and Ribavirin in Genotype 1 Infection
por: Kim, Do Young
Publicado: (2014)

Environmental Stability and Infectivity of Hepatitis C Virus (HCV) in Different Human Body Fluids
por: Pfaender, Stephanie, et al.
Publicado: (2018)

Effect of hepatic iron concentration and viral factors in chronic hepatitis C-infected patients with thalassemia major, treated with interferon and ribavirin
por: Jafroodi, Maryam, et al.
Publicado: (2011)

On the expected relationship between inbreeding, fitness, and extinction
por: Theodorou, Konstantinos, et al.
Publicado: (2006)

Extinction of Zika Virus and Usutu Virus by Lethal Mutagenesis Reveals Different Patterns of Sensitivity to Three Mutagenic Drugs
por: Bassi, Maria Rosaria, et al.
Publicado: (2018)

The natural compound silvestrol inhibits hepatitis E virus (HEV) replication in vitro and in vivo
por: Todt, Daniel, et al.
Publicado: (2018)

The optimal dose of ribavirin for chronic hepatitis C: From literature evidence to clinical practice: The optimal dose of ribavirin for chronic hepatitis C
por: Abenavoli, Ludovico, et al.
Publicado: (2011)

In vitro versus in vivo metabolic activation of mutagens.
por: Malling, H V, et al.
Publicado: (1973)

Why all blood donations should be tested for hepatitis E virus (HEV)
por: Denner, Joachim, et al.
Publicado: (2019)

Acute and chronic infections with nonprimate hepacivirus in young horses
por: Gather, Theresa, et al.
Publicado: (2016)

Nucleoside analogue 2’-C-methylcytidine inhibits hepatitis E virus replication but antagonizes ribavirin
por: Qu, Changbo, et al.
Publicado: (2017)

Ribavirin as a First Treatment Approach for Hepatitis E Virus Infection in Transplant Recipient Patients
por: Rivero-Juarez, Antonio, et al.
Publicado: (2019)

310 Ribavirin coupled to hemoglobin protects against viral hepatitis induced by the corona virus MHV-3 in mice
por: Levy, Gary A., et al.
Publicado: (2003)

Ribavirin
Publicado: (2016)

Ribavirin
por: Hall, Caroline Breese
Publicado: (1985)

Hepatitis E Virus Infection: Circulation, Molecular Epidemiology, and Impact on Global Health
por: Pallerla, Srinivas Reddy, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_jj67d281h4qasrt1ivdj7vj0oe