Gene Regulation and Quality Control in Murine Polyomavirus Infection

Murine polyomavirus (MPyV) infects mouse cells and is highly oncogenic in immunocompromised hosts and in other rodents. Its genome is a small, circular DNA molecule of just over 5000 base pairs and it encodes only seven polypeptides. While seemingly simply organized, this virus has adopted an unusua...

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Detalles Bibliográficos
Autor principal: Carmichael, Gordon G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086616/
https://www.ncbi.nlm.nih.gov/pubmed/27763514
http://dx.doi.org/10.3390/v8100284
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author Carmichael, Gordon G.
author_facet Carmichael, Gordon G.
author_sort Carmichael, Gordon G.
collection PubMed
description Murine polyomavirus (MPyV) infects mouse cells and is highly oncogenic in immunocompromised hosts and in other rodents. Its genome is a small, circular DNA molecule of just over 5000 base pairs and it encodes only seven polypeptides. While seemingly simply organized, this virus has adopted an unusual genome structure and some unusual uses of cellular quality control pathways that, together, allow an amazingly complex and varied pattern of gene regulation. In this review we discuss how MPyV leverages these various pathways to control its life cycle.
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spelling pubmed-50866162016-11-02 Gene Regulation and Quality Control in Murine Polyomavirus Infection Carmichael, Gordon G. Viruses Review Murine polyomavirus (MPyV) infects mouse cells and is highly oncogenic in immunocompromised hosts and in other rodents. Its genome is a small, circular DNA molecule of just over 5000 base pairs and it encodes only seven polypeptides. While seemingly simply organized, this virus has adopted an unusual genome structure and some unusual uses of cellular quality control pathways that, together, allow an amazingly complex and varied pattern of gene regulation. In this review we discuss how MPyV leverages these various pathways to control its life cycle. MDPI 2016-10-17 /pmc/articles/PMC5086616/ /pubmed/27763514 http://dx.doi.org/10.3390/v8100284 Text en © 2016 by the author; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Carmichael, Gordon G.
Gene Regulation and Quality Control in Murine Polyomavirus Infection
title Gene Regulation and Quality Control in Murine Polyomavirus Infection
title_full Gene Regulation and Quality Control in Murine Polyomavirus Infection
title_fullStr Gene Regulation and Quality Control in Murine Polyomavirus Infection
title_full_unstemmed Gene Regulation and Quality Control in Murine Polyomavirus Infection
title_short Gene Regulation and Quality Control in Murine Polyomavirus Infection
title_sort gene regulation and quality control in murine polyomavirus infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086616/
https://www.ncbi.nlm.nih.gov/pubmed/27763514
http://dx.doi.org/10.3390/v8100284
work_keys_str_mv AT carmichaelgordong generegulationandqualitycontrolinmurinepolyomavirusinfection

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