Crystal Structure of Ribosome-Inactivating Protein Ricin A Chain in Complex with the C-Terminal Peptide of the Ribosomal Stalk Protein P2

Ricin is a type 2 ribosome-inactivating protein (RIP), containing a catalytic A chain and a lectin-like B chain. It inhibits protein synthesis by depurinating the N-glycosidic bond at α-sarcin/ricin loop (SRL) of the 28S rRNA, which thereby prevents the binding of elongation factors to the GTPase ac...

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Detalles Bibliográficos
Autores principales: Shi, Wei-Wei, Tang, Yun-Sang, Sze, See-Yuen, Zhu, Zhen-Ning, Wong, Kam-Bo, Shaw, Pang-Chui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086656/
https://www.ncbi.nlm.nih.gov/pubmed/27754366
http://dx.doi.org/10.3390/toxins8100296

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