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First Trimester Phthalate Exposure and Infant Birth Weight in the Infant Development and Environment Study
Phthalate exposure is widespread among pregnant women but whether it is related to fetal growth and birth weight remains to be determined. We examined whether first trimester prenatal phthalate exposure was associated with birth weight in a pregnancy cohort study. We recruited first trimester pregna...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086684/ https://www.ncbi.nlm.nih.gov/pubmed/27669283 http://dx.doi.org/10.3390/ijerph13100945 |
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author | Sathyanarayana, Sheela Barrett, Emily Nguyen, Ruby Redmon, Bruce Haaland, Wren Swan, Shanna H. |
author_facet | Sathyanarayana, Sheela Barrett, Emily Nguyen, Ruby Redmon, Bruce Haaland, Wren Swan, Shanna H. |
author_sort | Sathyanarayana, Sheela |
collection | PubMed |
description | Phthalate exposure is widespread among pregnant women but whether it is related to fetal growth and birth weight remains to be determined. We examined whether first trimester prenatal phthalate exposure was associated with birth weight in a pregnancy cohort study. We recruited first trimester pregnant women from 2010–2012 from four centers and analyzed mother/infant dyads who had complete urinary phthalate and birth record data (N = 753). We conducted multiple linear regression to examine if prenatal log specific gravity adjusted urinary phthalate exposure was related to birthweight in term and preterm (≤37 weeks) infants, stratified by sex. We observed a significant association between mono carboxy-isononyl phthalate (MCOP) exposure and increased birthweight in term males, 0.13 kg (95% CI 0.03, 0.23). In preterm infants, we observed a 0.49 kg (95% CI 0.09, 0.89) increase in birthweight in relation to a one log unit change in the sum of di-ethylhexyl phthalate (DEHP) metabolite concentrations in females (N = 33). In summary, we observed few associations between prenatal phthalate exposure and birthweight. Positive associations may be attributable to unresolved confounding in term infants and limited sample size in preterm infants. |
format | Online Article Text |
id | pubmed-5086684 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-50866842016-11-02 First Trimester Phthalate Exposure and Infant Birth Weight in the Infant Development and Environment Study Sathyanarayana, Sheela Barrett, Emily Nguyen, Ruby Redmon, Bruce Haaland, Wren Swan, Shanna H. Int J Environ Res Public Health Article Phthalate exposure is widespread among pregnant women but whether it is related to fetal growth and birth weight remains to be determined. We examined whether first trimester prenatal phthalate exposure was associated with birth weight in a pregnancy cohort study. We recruited first trimester pregnant women from 2010–2012 from four centers and analyzed mother/infant dyads who had complete urinary phthalate and birth record data (N = 753). We conducted multiple linear regression to examine if prenatal log specific gravity adjusted urinary phthalate exposure was related to birthweight in term and preterm (≤37 weeks) infants, stratified by sex. We observed a significant association between mono carboxy-isononyl phthalate (MCOP) exposure and increased birthweight in term males, 0.13 kg (95% CI 0.03, 0.23). In preterm infants, we observed a 0.49 kg (95% CI 0.09, 0.89) increase in birthweight in relation to a one log unit change in the sum of di-ethylhexyl phthalate (DEHP) metabolite concentrations in females (N = 33). In summary, we observed few associations between prenatal phthalate exposure and birthweight. Positive associations may be attributable to unresolved confounding in term infants and limited sample size in preterm infants. MDPI 2016-09-23 2016-10 /pmc/articles/PMC5086684/ /pubmed/27669283 http://dx.doi.org/10.3390/ijerph13100945 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sathyanarayana, Sheela Barrett, Emily Nguyen, Ruby Redmon, Bruce Haaland, Wren Swan, Shanna H. First Trimester Phthalate Exposure and Infant Birth Weight in the Infant Development and Environment Study |
title | First Trimester Phthalate Exposure and Infant Birth Weight in the Infant Development and Environment Study |
title_full | First Trimester Phthalate Exposure and Infant Birth Weight in the Infant Development and Environment Study |
title_fullStr | First Trimester Phthalate Exposure and Infant Birth Weight in the Infant Development and Environment Study |
title_full_unstemmed | First Trimester Phthalate Exposure and Infant Birth Weight in the Infant Development and Environment Study |
title_short | First Trimester Phthalate Exposure and Infant Birth Weight in the Infant Development and Environment Study |
title_sort | first trimester phthalate exposure and infant birth weight in the infant development and environment study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086684/ https://www.ncbi.nlm.nih.gov/pubmed/27669283 http://dx.doi.org/10.3390/ijerph13100945 |
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