Cargando…

First Trimester Phthalate Exposure and Infant Birth Weight in the Infant Development and Environment Study

Phthalate exposure is widespread among pregnant women but whether it is related to fetal growth and birth weight remains to be determined. We examined whether first trimester prenatal phthalate exposure was associated with birth weight in a pregnancy cohort study. We recruited first trimester pregna...

Descripción completa

Detalles Bibliográficos
Autores principales: Sathyanarayana, Sheela, Barrett, Emily, Nguyen, Ruby, Redmon, Bruce, Haaland, Wren, Swan, Shanna H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086684/
https://www.ncbi.nlm.nih.gov/pubmed/27669283
http://dx.doi.org/10.3390/ijerph13100945
_version_ 1782463779306471424
author Sathyanarayana, Sheela
Barrett, Emily
Nguyen, Ruby
Redmon, Bruce
Haaland, Wren
Swan, Shanna H.
author_facet Sathyanarayana, Sheela
Barrett, Emily
Nguyen, Ruby
Redmon, Bruce
Haaland, Wren
Swan, Shanna H.
author_sort Sathyanarayana, Sheela
collection PubMed
description Phthalate exposure is widespread among pregnant women but whether it is related to fetal growth and birth weight remains to be determined. We examined whether first trimester prenatal phthalate exposure was associated with birth weight in a pregnancy cohort study. We recruited first trimester pregnant women from 2010–2012 from four centers and analyzed mother/infant dyads who had complete urinary phthalate and birth record data (N = 753). We conducted multiple linear regression to examine if prenatal log specific gravity adjusted urinary phthalate exposure was related to birthweight in term and preterm (≤37 weeks) infants, stratified by sex. We observed a significant association between mono carboxy-isononyl phthalate (MCOP) exposure and increased birthweight in term males, 0.13 kg (95% CI 0.03, 0.23). In preterm infants, we observed a 0.49 kg (95% CI 0.09, 0.89) increase in birthweight in relation to a one log unit change in the sum of di-ethylhexyl phthalate (DEHP) metabolite concentrations in females (N = 33). In summary, we observed few associations between prenatal phthalate exposure and birthweight. Positive associations may be attributable to unresolved confounding in term infants and limited sample size in preterm infants.
format Online
Article
Text
id pubmed-5086684
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-50866842016-11-02 First Trimester Phthalate Exposure and Infant Birth Weight in the Infant Development and Environment Study Sathyanarayana, Sheela Barrett, Emily Nguyen, Ruby Redmon, Bruce Haaland, Wren Swan, Shanna H. Int J Environ Res Public Health Article Phthalate exposure is widespread among pregnant women but whether it is related to fetal growth and birth weight remains to be determined. We examined whether first trimester prenatal phthalate exposure was associated with birth weight in a pregnancy cohort study. We recruited first trimester pregnant women from 2010–2012 from four centers and analyzed mother/infant dyads who had complete urinary phthalate and birth record data (N = 753). We conducted multiple linear regression to examine if prenatal log specific gravity adjusted urinary phthalate exposure was related to birthweight in term and preterm (≤37 weeks) infants, stratified by sex. We observed a significant association between mono carboxy-isononyl phthalate (MCOP) exposure and increased birthweight in term males, 0.13 kg (95% CI 0.03, 0.23). In preterm infants, we observed a 0.49 kg (95% CI 0.09, 0.89) increase in birthweight in relation to a one log unit change in the sum of di-ethylhexyl phthalate (DEHP) metabolite concentrations in females (N = 33). In summary, we observed few associations between prenatal phthalate exposure and birthweight. Positive associations may be attributable to unresolved confounding in term infants and limited sample size in preterm infants. MDPI 2016-09-23 2016-10 /pmc/articles/PMC5086684/ /pubmed/27669283 http://dx.doi.org/10.3390/ijerph13100945 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sathyanarayana, Sheela
Barrett, Emily
Nguyen, Ruby
Redmon, Bruce
Haaland, Wren
Swan, Shanna H.
First Trimester Phthalate Exposure and Infant Birth Weight in the Infant Development and Environment Study
title First Trimester Phthalate Exposure and Infant Birth Weight in the Infant Development and Environment Study
title_full First Trimester Phthalate Exposure and Infant Birth Weight in the Infant Development and Environment Study
title_fullStr First Trimester Phthalate Exposure and Infant Birth Weight in the Infant Development and Environment Study
title_full_unstemmed First Trimester Phthalate Exposure and Infant Birth Weight in the Infant Development and Environment Study
title_short First Trimester Phthalate Exposure and Infant Birth Weight in the Infant Development and Environment Study
title_sort first trimester phthalate exposure and infant birth weight in the infant development and environment study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086684/
https://www.ncbi.nlm.nih.gov/pubmed/27669283
http://dx.doi.org/10.3390/ijerph13100945
work_keys_str_mv AT sathyanarayanasheela firsttrimesterphthalateexposureandinfantbirthweightintheinfantdevelopmentandenvironmentstudy
AT barrettemily firsttrimesterphthalateexposureandinfantbirthweightintheinfantdevelopmentandenvironmentstudy
AT nguyenruby firsttrimesterphthalateexposureandinfantbirthweightintheinfantdevelopmentandenvironmentstudy
AT redmonbruce firsttrimesterphthalateexposureandinfantbirthweightintheinfantdevelopmentandenvironmentstudy
AT haalandwren firsttrimesterphthalateexposureandinfantbirthweightintheinfantdevelopmentandenvironmentstudy
AT swanshannah firsttrimesterphthalateexposureandinfantbirthweightintheinfantdevelopmentandenvironmentstudy