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l-Arginine Enhances Resistance against Oxidative Stress and Heat Stress in Caenorhabditis elegans

The antioxidant properties of l-arginine (l-Arg) in vivo, and its effect on enhancing resistance to oxidative stress and heat stress in Caenorhabditis elegans were investigated. C. elegans, a worm model popularly used in molecular and developmental biology, was used in the present study. Here, we re...

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Detalles Bibliográficos
Autores principales: Ma, Heran, Ma, Yudan, Zhang, Zhixian, Zhao, Ziyuan, Lin, Ran, Zhu, Jinming, Guo, Yi, Xu, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086708/
https://www.ncbi.nlm.nih.gov/pubmed/27690079
http://dx.doi.org/10.3390/ijerph13100969
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author Ma, Heran
Ma, Yudan
Zhang, Zhixian
Zhao, Ziyuan
Lin, Ran
Zhu, Jinming
Guo, Yi
Xu, Li
author_facet Ma, Heran
Ma, Yudan
Zhang, Zhixian
Zhao, Ziyuan
Lin, Ran
Zhu, Jinming
Guo, Yi
Xu, Li
author_sort Ma, Heran
collection PubMed
description The antioxidant properties of l-arginine (l-Arg) in vivo, and its effect on enhancing resistance to oxidative stress and heat stress in Caenorhabditis elegans were investigated. C. elegans, a worm model popularly used in molecular and developmental biology, was used in the present study. Here, we report that l-Arg, at a concentration of 1 mM, prolonged C. elegans life by 26.98% and 37.02% under oxidative and heat stress, respectively. Further experiments indicated that the longevity-extending effects of l-Arg may be exerted by its free radical scavenging capacity and the upregulation of aging-associated gene expression in worms. This work is important in the context of numerous recent studies that concluded that environment stresses are associated with an increased population death rate.
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spelling pubmed-50867082016-11-02 l-Arginine Enhances Resistance against Oxidative Stress and Heat Stress in Caenorhabditis elegans Ma, Heran Ma, Yudan Zhang, Zhixian Zhao, Ziyuan Lin, Ran Zhu, Jinming Guo, Yi Xu, Li Int J Environ Res Public Health Article The antioxidant properties of l-arginine (l-Arg) in vivo, and its effect on enhancing resistance to oxidative stress and heat stress in Caenorhabditis elegans were investigated. C. elegans, a worm model popularly used in molecular and developmental biology, was used in the present study. Here, we report that l-Arg, at a concentration of 1 mM, prolonged C. elegans life by 26.98% and 37.02% under oxidative and heat stress, respectively. Further experiments indicated that the longevity-extending effects of l-Arg may be exerted by its free radical scavenging capacity and the upregulation of aging-associated gene expression in worms. This work is important in the context of numerous recent studies that concluded that environment stresses are associated with an increased population death rate. MDPI 2016-09-29 2016-10 /pmc/articles/PMC5086708/ /pubmed/27690079 http://dx.doi.org/10.3390/ijerph13100969 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ma, Heran
Ma, Yudan
Zhang, Zhixian
Zhao, Ziyuan
Lin, Ran
Zhu, Jinming
Guo, Yi
Xu, Li
l-Arginine Enhances Resistance against Oxidative Stress and Heat Stress in Caenorhabditis elegans
title l-Arginine Enhances Resistance against Oxidative Stress and Heat Stress in Caenorhabditis elegans
title_full l-Arginine Enhances Resistance against Oxidative Stress and Heat Stress in Caenorhabditis elegans
title_fullStr l-Arginine Enhances Resistance against Oxidative Stress and Heat Stress in Caenorhabditis elegans
title_full_unstemmed l-Arginine Enhances Resistance against Oxidative Stress and Heat Stress in Caenorhabditis elegans
title_short l-Arginine Enhances Resistance against Oxidative Stress and Heat Stress in Caenorhabditis elegans
title_sort l-arginine enhances resistance against oxidative stress and heat stress in caenorhabditis elegans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086708/
https://www.ncbi.nlm.nih.gov/pubmed/27690079
http://dx.doi.org/10.3390/ijerph13100969
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