Enantioselective Synthesis of 4- and 6-Azaindolines by a Cation-Directed Cyclization

[Image: see text] Functionalized 4- and 6-azaindolines are accessible with high levels of enantioselectivity by the cation-directed cyclization of aminopyridine-derived imines via phase-transfer catalysis. The extension of this methodology to diastereoselective cyclizations is also described.

Detalles Bibliográficos
Autores principales: Lamb, Alan D., Davey, Peter D., Driver, Russell W., Thompson, Amber L., Smith, Martin D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086784/
https://www.ncbi.nlm.nih.gov/pubmed/27709963
http://dx.doi.org/10.1021/acs.orglett.6b02744
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author Lamb, Alan D.
Davey, Peter D.
Driver, Russell W.
Thompson, Amber L.
Smith, Martin D.
author_facet Lamb, Alan D.
Davey, Peter D.
Driver, Russell W.
Thompson, Amber L.
Smith, Martin D.
author_sort Lamb, Alan D.
collection PubMed
description [Image: see text] Functionalized 4- and 6-azaindolines are accessible with high levels of enantioselectivity by the cation-directed cyclization of aminopyridine-derived imines via phase-transfer catalysis. The extension of this methodology to diastereoselective cyclizations is also described.
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spelling pubmed-50867842016-11-01 Enantioselective Synthesis of 4- and 6-Azaindolines by a Cation-Directed Cyclization Lamb, Alan D. Davey, Peter D. Driver, Russell W. Thompson, Amber L. Smith, Martin D. Org Lett [Image: see text] Functionalized 4- and 6-azaindolines are accessible with high levels of enantioselectivity by the cation-directed cyclization of aminopyridine-derived imines via phase-transfer catalysis. The extension of this methodology to diastereoselective cyclizations is also described. American Chemical Society 2016-10-06 2016-10-21 /pmc/articles/PMC5086784/ /pubmed/27709963 http://dx.doi.org/10.1021/acs.orglett.6b02744 Text en Copyright © 2016 American Chemical Society This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) , which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
spellingShingle Lamb, Alan D.
Davey, Peter D.
Driver, Russell W.
Thompson, Amber L.
Smith, Martin D.
Enantioselective Synthesis of 4- and 6-Azaindolines by a Cation-Directed Cyclization
title Enantioselective Synthesis of 4- and 6-Azaindolines by a Cation-Directed Cyclization
title_full Enantioselective Synthesis of 4- and 6-Azaindolines by a Cation-Directed Cyclization
title_fullStr Enantioselective Synthesis of 4- and 6-Azaindolines by a Cation-Directed Cyclization
title_full_unstemmed Enantioselective Synthesis of 4- and 6-Azaindolines by a Cation-Directed Cyclization
title_short Enantioselective Synthesis of 4- and 6-Azaindolines by a Cation-Directed Cyclization
title_sort enantioselective synthesis of 4- and 6-azaindolines by a cation-directed cyclization
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086784/
https://www.ncbi.nlm.nih.gov/pubmed/27709963
http://dx.doi.org/10.1021/acs.orglett.6b02744
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