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Ubc13 haploinsufficiency protects against age-related insulin resistance and high-fat diet-induced obesity
Obesity is associated with low-grade inflammation that leads to insulin resistance and type 2 diabetes via Toll-like Receptor (TLR) and TNF-family cytokine receptor (TNFR) signaling pathways. Ubc13 is an ubiquitin-conjugating enzyme responsible for non-canonical K63-linked polyubiquitination of TNF...
Autores principales: | Joo, Erina, Fukushima, Toru, Harada, Norio, Reed, John C., Matsuzawa, Shu-ichi, Inagaki, Nobuya |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086849/ https://www.ncbi.nlm.nih.gov/pubmed/27796312 http://dx.doi.org/10.1038/srep35983 |
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