Vectorization in an oncolytic vaccinia virus of an antibody, a Fab and a scFv against programmed cell death -1 (PD-1) allows their intratumoral delivery and an improved tumor-growth inhibition

We report here the successful vectorization of a hamster monoclonal IgG (namely J43) recognizing the murine Programmed cell death-1 (mPD-1) in Western Reserve (WR) oncolytic vaccinia virus. Three forms of mPD-1 binders have been inserted into the virus: whole antibody (mAb), Fragment antigen-binding...

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Detalles Bibliográficos
Autores principales: Kleinpeter, Patricia, Fend, Laetitia, Thioudellet, Christine, Geist, Michel, Sfrontato, Nathalie, Koerper, Véronique, Fahrner, Catherine, Schmitt, Doris, Gantzer, Murielle, Remy-Ziller, Christelle, Brandely, Renée, Villeval, Dominique, Rittner, Karola, Silvestre, Nathalie, Erbs, Philippe, Zitvogel, Laurence, Quéméneur, Eric, Préville, Xavier, Marchand, Jean-Baptiste
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087307/
https://www.ncbi.nlm.nih.gov/pubmed/27853644
http://dx.doi.org/10.1080/2162402X.2016.1220467

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